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Stockholders' Equity (Tables)
 6 Months Ended
Jun. 30, 2019
Share-based Payment Arrangement [Abstract]  
Schedule of Employee Service Share-based Compensation Allocation
Total share-based compensation expense by statement of operations and comprehensive loss classification is presented below (in thousands):
 
Three Months Ended June 30,
 
Six Months Ended June 30,
 
2019
 
2018
 
2019
 
2018
Research and development expense
$
6,611

 
$
1,771

 
$
11,768

 
$
3,264

General and administrative expense
5,978

 
2,103

 
11,952

 
4,270

 
$
12,589

 
$
3,874

 
$
23,720

 
$
7,534