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Stockholders' Equity (Tables)
3 Months Ended
Mar. 31, 2019
Disclosure of Compensation Related Costs, Share-based Payments [Abstract]  
Schedule of Employee Service Share-based Compensation Allocation
Total share-based compensation expense by statement of operations classification is presented below (in thousands):
 
Three Months Ended March 31,
 
2019
 
2018
Research and development expense
$
5,157

 
$
1,493

General and administrative expense
5,974

 
2,167

 
$
11,131

 
$
3,660