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Stock-based compensation (Tables)
 6 Months Ended
Jun. 30, 2018
Disclosure of Compensation Related Costs, Share-based Payments [Abstract]  
Schedule of Employee Service Share-based Compensation Allocation
Total share-based compensation expense by statement of operations and comprehensive loss classification is presented below (in thousands):
 
Three Months Ended June 30,
 
Six Months Ended June 30,
 
2018
 
2017
 
2018
 
2017
Research and development expense
$
1,771

 
$
938

 
$
3,264

 
$
1,919

General and administrative expense
2,103

 
1,285

 
4,270

 
2,070

 
$
3,874

 
$
2,223

 
$
7,534

 
$
3,989