CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($) $ in Thousands	3 Months Ended	9 Months Ended
Sep. 30, 2016	Sep. 30, 2015	Sep. 30, 2016	Sep. 30, 2015
Expenses
Research and development	$ 16,106	$ 14,563	$ 52,535	$ 34,046
General and administrative	3,475	4,161	11,391	12,180
Total operating expenses	19,581	18,724	63,926	46,226
Loss from operations	(19,581)	(18,724)	(63,926)	(46,226)
Other income, net	160	(17)	530	99
Net loss	(19,421)	(18,741)	(63,396)	(46,127)
Unrealized gain (loss) on available-for-sale investments	(34)	6	26	2
Comprehensive loss	$ (19,455)	$ (18,735)	$ (63,370)	$ (46,125)
Basic and diluted net loss per share	$ (0.97)	$ (1.11)	$ (3.21)	$ (2.86)
Weighted average number of shares used in computing net loss per share, basic and diluted	19,924,005	16,841,954	19,739,935	16,103,326

Amount after tax of increase (decrease) in equity from transactions and other events and circumstances from net income and other comprehensive income, attributable to parent entity. Excludes changes in equity resulting from investments by owners and distributions to owners.

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