CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($) $ in Thousands	3 Months Ended
Mar. 31, 2016	Mar. 31, 2015
Expenses
Research and development	$ 17,988	$ 8,207
General and administrative	4,130	3,779
Total operating expenses	22,118	11,986
Loss from operations	(22,118)	(11,986)
Other income, net	204	46
Net loss	(21,914)	(11,940)
Unrealized gain on available-for-sale investments	27	5
Comprehensive loss	$ (21,887)	$ (11,935)
Basic and diluted net loss per share	$ (1.13)	$ (0.77)
Weighted average number of shares used in computing net loss per share, basic and diluted	19,380,840	15,453,534

Amount after tax of increase (decrease) in equity from transactions and other events and circumstances from net income and other comprehensive income, attributable to parent entity. Excludes changes in equity resulting from investments by owners and distributions to owners.

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