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CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2015
Dec. 31, 2014
Dec. 31, 2013
Expenses      
Research and development $ 48,959 $ 26,071 $ 19,797
General and administrative 15,755 12,699 11,177
Restructuring costs 0 334 1,025
Total operating expenses 64,714 39,104 31,999
Loss from operations (64,714) (39,104) (31,999)
Other income (expense), net 170 (77) (1,084)
Change in fair value of warrant liability 0 (4,517) (19,799)
Loss before income taxes (64,544) (43,698) (52,882)
Income tax benefit 0 0 23
Net loss (64,544) (43,698) (52,859)
Unrealized gain (loss) on available-for-sale investments (37) (14) 13
Comprehensive loss $ (64,507) $ (43,684) $ (52,872)
Loss per share, basic (in US$ per share) $ (3.82) $ (3.24)  
Basic and diluted net loss per share (in dollars per share)     $ (4.78)
Weighted average number of shares used in computing net loss per share, basic and diluted (in shares) 16,901,826 13,483,467 11,057,040