CONSOLIDATED STATEMENTS OF CASH FLOWS (USD $) In Thousands, unless otherwise specified	12 Months Ended
Dec. 31, 2014	Dec. 31, 2013	Dec. 31, 2012
Operating activities
Net loss	$ (43,698)us-gaap_NetIncomeLoss	$ (52,859)us-gaap_NetIncomeLoss	$ (20,286)us-gaap_NetIncomeLoss
Non-cash adjustments reconciling net loss to operating cash flows
Depreciation of property and equipment	199us-gaap_Depreciation	171us-gaap_Depreciation	123us-gaap_Depreciation
Amortization of premium on investments	534	0	0
Share-based compensation expense	7,050us-gaap_ShareBasedCompensation	1,823us-gaap_ShareBasedCompensation	2,009us-gaap_ShareBasedCompensation
Loss on disposal of property and equipment	0	40	0
Change in lease incentive liability	0us-gaap_AmortizationOfLeaseIncentives	(70)us-gaap_AmortizationOfLeaseIncentives	85us-gaap_AmortizationOfLeaseIncentives
Change in fair value of warrant liability	4,517us-gaap_FairValueAdjustmentOfWarrants	19,799us-gaap_FairValueAdjustmentOfWarrants	0us-gaap_FairValueAdjustmentOfWarrants
Change in fair value adjustment of share-based compensation liability	0	1,369	0
Change in restructuring costs	13us-gaap_RestructuringCosts	0us-gaap_RestructuringCosts	0us-gaap_RestructuringCosts
Changes in operating assets and liabilities
Other current assets	(1,209)	340	(15)
Other assets	(326)	0	0
Accounts payable and accrued liabilities	151	(68)	1,434
Other liabilities	21	0	0
Cash flows used for operating activities	(32,748)	(29,455)	(16,650)
Investing activities:
Purchases of short-term investments	(10,468)us-gaap_PaymentsToAcquireInvestments	(68,408)us-gaap_PaymentsToAcquireInvestments	(29,431)us-gaap_PaymentsToAcquireInvestments
Disposal and maturities of short-term investments	35,073	39,138	29,716
Purchases of property and equipment	(386)	(204)	(230)
Proceeds from disposal of property and equipment	0	4	0
Cash flows provided by / (used for) investing activities	24,219	(29,470)	55
Financing activities:
Proceeds from issuance of common stock, net of issuance costs	0	54,196	19,886
Proceeds from issuance of warrants, net of issuance costs	0us-gaap_ProceedsFromIssuanceOfWarrants	0us-gaap_ProceedsFromIssuanceOfWarrants	4,927us-gaap_ProceedsFromIssuanceOfWarrants
Proceeds from exercise of common stock options and warrants	887	561	0
Cash flows provided by financing activities	887	54,757	24,813
Increase / (decrease) in cash and cash equivalents	(7,642)	(4,168)	8,218
Effect of exchange rate changes on cash and cash equivalents	0	0	303
Cash and cash equivalents, beginning of year	14,235	18,403	9,882
Cash and cash equivalents, end of year	6,593	14,235	18,403
Income taxes paid	0us-gaap_IncomeTaxesPaid	35us-gaap_IncomeTaxesPaid	34us-gaap_IncomeTaxesPaid
Net exercise of warrants	$ 993	$ 2,586	$ 0

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- Definition

The aggregate amount of noncash, equity-based employee remuneration. This may include the value of stock or unit options, amortization of restricted stock or units, and adjustment for officers' compensation. As noncash, this element is an add back when calculating net cash generated by operating activities using the indirect method.

+ References

+ Details

Name:	us-gaap_ShareBasedCompensation
Namespace Prefix:	us-gaap_
Data Type:	xbrli:monetaryItemType
Balance Type:	debit
Period Type:	duration