144 0001574591 XXXXXXXX LIVE 0001157601 Madrigal Pharmaceuticals, Inc. 001-33277 Four Towers Bridge 200 Barr Harbor Drive, Suite 200 West Conshohocken PA 19428 267-824-2827 Mardi Dier Officer Common Stock Morgan Stanley Smith Barney LLC Executive Financial Services

1 New York Plaza, 8th Floor New York NY 10004

646 283813.64 22939969 03/06/2026 Nasdaq Stock Market Common Stock 03/05/2026 Restricted Stock Unit Grant Issuer N 646 03/06/2026 Vesting of Restricted Stock Units N Mardi Dier

c/o Madrigal Pharmaceuticals, Inc. 200 Barr Harbor Drive, Suite 200 West Conshohocken PA 19428

Common Stock 03/06/2026 1336 586958.24 Mardi Dier

c/o Madrigal Pharmaceuticals, Inc. 200 Barr Harbor Drive, Suite 200 West Conshohocken PA 19428

Common Stock 03/02/2026 1183 505389.43 The sale of shares of common stock reported on this Form 144 represents the sale of shares pursuant to a sell-to-cover transaction in order to satisfy tax withholding obligations in connection with the vesting of Restricted Stock Units previously granted to the Reporting Person. 03/06/2026 /s/ Mardi Dier