144 0001574591 XXXXXXXX LIVE 0001157601 Madrigal Pharmaceuticals, Inc. 001-33277 Four Towers Bridge 200 Barr Harbor Drive, Suite 200 West Conshohocken PA 19428 267-824-2827 Mardi Dier Officer Common Stock Morgan Stanley Smith Barney LLC Executive Financial Services

1 New York Plaza, 8th Floor New York NY 10004

1187 386833.69 22080246 03/03/2025 Nasdaq Stock Market Common Stock Morgan Stanley Smith Barney LLC Executive Financial Services

1 New York Plaza, 8th Floor New York NY 10004

774 250416.63 22080246 03/03/2025 Nasdaq Stock Market Common Stock Morgan Stanley Smith Barney LLC Executive Financial Services

1 New York Plaza, 8th Floor New York NY 10004

258 80875.26 22080246 03/10/2025 Nasdaq Stock Market Common Stock 03/01/2025 Restricted Stock Unit Grant Issuer N 1187 03/01/2025 Vesting of Restricted Stock Units Common Stock 03/01/2025 Restricted Stock Unit Grant Issuer N 774 03/01/2025 Vesting of Restricted Stock Units Common Stock 03/01/2025 Restricted Stock Unit Grant Issuer N 258 03/01/2025 Vesting of Restricted Stock Units Y The sale of shares of common stock reported on this Form 144 represents (i) the sale of shares pursuant to a sell-to-cover transaction in order to satisfy tax withholding obligations in connection with the vesting of Restricted Stock Units previously granted to the Reporting Person and (ii) the sale of shares pursuant to a 10b5-1 Plan applicable to the Reporting Person. Aggregate Market Value of future sales is based on a closing price of $313.47 for the Issuer's Common Stock on March 3, 2025. 03/03/2025 11/13/2024 /s/Mardi Dier