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Significant Agreements - Additional Information (Detail) - USD ($)
12 Months Ended
Jun. 09, 2017
Dec. 31, 2020
Dec. 31, 2018
Dec. 31, 2017
Other Commitments [Line Items]        
Milestones payments     $ 0  
Research and development expense     $ 12,966,000 $ 10,243,000
License Agreement [Member]        
Other Commitments [Line Items]        
License fee $ 1,000,000,000      
License agreement termination description     the License Agreement may be terminated (i) by the Company for any reason upon 120 days’ advance notice to RespiVert; (ii) by RespiVert upon receipt of notice from the Company of either voluntary or involuntary insolvency proceedings of the Company; and (iii) by either party for a material breach which remains uncured following the applicable cure period.  
License agreement termination notice period     120 days  
Research and development expense       $ 1,000,000,000
License Agreement [Member] | Maximum [Member]        
Other Commitments [Line Items]        
Range of royalties based on sales, percentage 10.00%      
License Agreement [Member] | Minimum [Member]        
Other Commitments [Line Items]        
Range of royalties based on sales, percentage 6.00%      
License Agreement [Member] | Scenario Forecast [Member]        
Other Commitments [Line Items]        
Development milestone payment   $ 1,000,000,000    
Development milestone payment period   10 days    
Development and Commercial Milestones [Member] | License Agreement [Member] | Maximum [Member]        
Other Commitments [Line Items]        
Milestones payments $ 1,000,000,000      
Development and Commercial Milestones [Member] | License Agreement [Member] | Minimum [Member]        
Other Commitments [Line Items]        
Milestones payments $ 80,000,000,000