EX-99.1 2 tm2429141d1_ex99-1.htm EXHIBIT 99.1

 

Exhibit 99.1

 

ADDEX THERAPEUTICS LTD

 

INDEX TO UNAUDITED INTERIM CONDENSED CONSOLIDATED FINANCIAL STATEMENTS

 

Unaudited Interim Condensed Consolidated Financial Statements  
Unaudited Interim Condensed Consolidated Balance Sheets as of September 30, 2024 and December 31, 2023 2
Unaudited Interim Condensed Consolidated Statements of Profit or Loss for the three-month and nine-month periods ended September 30, 2024 and 2023 3
Unaudited Interim Condensed Consolidated Statements of Comprehensive Income or Loss for the three-month and nine-month periods ended September 30, 2024 and 2023 4
Unaudited Interim Condensed Consolidated Statements of Changes in Equity for the nine-month periods ended September 30, 2024 and 2023 5
Unaudited Interim Condensed Consolidated Statements of Changes in Equity for the three-month period ended September 30, 2023 6
Unaudited Interim Condensed Consolidated Statements of Changes in Equity for the three-month period ended September 30, 2024 7
Unaudited Interim Condensed Consolidated Statements of Cash Flows for the nine-month periods ended September 30, 2024 and 2023 8
Unaudited Notes to the Interim Condensed Consolidated Financial Statements for the nine-month period ended September 30, 2024 9

 

 

 

 

Addex Therapeutics │ Unaudited Interim Condensed Consolidated Financial Statements

 

Unaudited Interim Condensed Consolidated Balance Sheets

 

as of September 30, 2024, and December 31, 2023

 

   Notes   September 30, 
2024		   December 31,
2023		 
             
       Amounts in Swiss francs 
ASSETS               
                
Current assets               
Cash and cash equivalents   6    3,349,180    3,865,481 
Other financial assets   7/13    4,946    848 
Trade and other receivables   7    480,006    110,361 
Contract asset   7    36,502    40,907 
Prepayments   7    196,335    217,008 
Other current assets   7    5,000    - 
Total current assets        4,071,969    4,234,605 
                
Non-current assets               
Right-of-use assets   8    43,590    330,332 
Intangible assets   10    21,685    - 
Property, plant and equipment   9    1,238    22,604 
Non-current financial assets   11    7,058    54,344 
Investment accounted for using the equity method   22    8,022,718    - 
Total non-current assets        8,096,289    407,280 
                
Total assets        12,168,258    4,641,885 
                
LIABILITIES AND EQUITY               
                
Current liabilities               
Current lease liabilities        7,215    273,956 
Payables and accruals   12    880,349    2,384,350 
Deferred income        -    234,978 
Total current liabilities        887,564    2,893,284 
                
Non-current liabilities               
Non-current lease liabilities        36,552    70,380 
Retirement benefits obligations   15    181,914    443,524 
Deferred income        -    89,232 
Total non-current liabilities        218,466    603,136 
                
Equity               
Share capital   13    1,843,545    1,843,545 
Share premium   13    266,383,945    266,194,689 
Other equity   13    64,620,223    64,620,223 
Treasury shares reserve   13    (872,533)   (909,566)
Other reserves        31,243,767    29,814,816 
Accumulated deficit        (352,156,719)   (360,418,242)
Total equity        11,062,228    1,145,465 
                
Total liabilities and equity        12,168,258    4,641,885 

 

The accompanying notes form an integral part of these consolidated financial statements.

 

2 

 

 

Addex Therapeutics │ Unaudited Interim Condensed Consolidated Financial Statements

 

Unaudited Interim Condensed Consolidated Statements of Profit or Loss

 

for the three-month and nine-month periods ended September 30, 2024 and 2023

 

       For the three months ended
September 30,		   For the nine months ended
September 30,		 
   Notes   2024   2023*   2024   2023* 
                     
   Amounts in Swiss francs 
Revenue from contract with customer   16    53,837    327,733    402,594    1,459,502 
Other income   17    4,510    1,485    5,940    3,740 
                          
Operating costs                         
Research and development        (204,514)   (490,687)   (788,956)   (1,037,629)
General and administration        (476,032)   (587,769)   (1,929,185)   (1,938,689)
Total operating costs   18    (680,546)   (1,078,456)   (2,718,141)   (2,976,318)
Operating loss        (622,199)   (749,238)   (2,309,607)   (1,513,076)
Finance income        (18,513)   13,658    9,180    50,833 
Finance expense        (11,927)   24,844    (13,402)   (139,898)
Finance result   20    (30,440)   38,502    (4,222)   (89,065)
Share of net loss of investments accounted for using the equity method   22    (874,933)   -    (1,405,682)   - 
Net loss before tax         (1,527,572)   (710,736)   (3,719,511)   (1,602,141)
Income tax expense        -    -    -    - 
Net loss from continuing operations        (1,527,572)   (710,736)   (3,719,511)   (1,602,141)
Net profit / (loss) from discontinued operations (attributable to equity holders of the Group)   21    (2,400)   (1,906,334)   11,981,034    (6,097,250)
Net profit / (loss) for the period        (1,529,972)   (2,617,070)   8,261,523    (7,699,391)
                          
Basic profit / (loss) per share for profit/(loss) attributable to the ordinary equity holders of the Company   23    (0.02)   (0.03)   0.08    (0.11)
From continuing operations        (0.02)   (0.01)   (0.04)   (0.02)
From discontinued operations        -    (0.02)   0.12    (0.09)
                          
Diluted profit / (loss) per share for profit/ (loss) attributable to the ordinary equity holders of the Company   23    (0.02)   (0.03)   0.05    (0.11)
From continuing operations        (0.02)   (0.01)   (0.04)   (0.02)
From discontinued operations        -    (0.02)   0.07    (0.09)

 

* The comparative information has been re-presented due to discontinued operations that have been reclassed to the financial line called “Net profit or loss from discontinued operations” (note 21). In the other sections of these unaudited interim condensed consolidated financial statements an asterisk will indicate where comparative information has been re-presented.

 

The accompanying notes form an integral part of these consolidated financial statements.

 

3 

 

 

Addex Therapeutics │ Unaudited Interim Condensed Consolidated Financial Statements

 

Unaudited Interim Condensed Consolidated Statements of Comprehensive Income or Loss

 

for the three-month and nine-month periods ended September 30, 2024 and 2023

 

   For the three months ended September 30,   For the nine months ended September 30, 
   2024   2023*   2024   2023* 
                 
   Amounts in Swiss francs 
Net profit / (loss) for the period   (1,529,972)   (2,617,070)   8,261,523    (7,699,391)
                     
Other comprehensive income / (loss)                    
Items that will never be reclassified to profit and loss:                    
Remeasurements of retirement benefits obligation related to continuing operations   (99,408)   (1,261)   (154,163)   (9,559)
Remeasurements of retirement benefits obligation related to discontinued operations.   -    (23,911)   (47,348)   (181,266)
Items that may be classified subsequently to profit and loss:                    
Exchange difference on translation of foreign operations   (296)   (259)   689    (1,157)
Other comprehensive income / (loss) for the period, net of tax   (99,704)   (25,431)   (200,822)   (191,982)
                     
Total comprehensive income / (loss) for the period   (1,629,676)   (2,642,501)   8,060,701    (7,891,373)
From continuing operations   (1,627,276)   (712,256)   (3,872,985)   (1,612,857)
From discontinued operations   (2,400)   (1,930,245)   11,933,686    (6,278,516)

 

The accompanying notes form an integral part of these consolidated financial statements.

 

4 

 

 

Addex Therapeutics │ Unaudited Interim Condensed Consolidated Financial Statements

 

Unaudited Interim Condensed Consolidated Statements of Changes in Equity

 

for the nine-month periods ended September 30, 2024 and 2023

 

    Notes  Share Capital   Share
Premium		   Other
Equity		   Treasury
Shares
Reserve		   Foreign
Currency
Translation
Reserve		   Other
Reserves		   Accumulated
Deficit		   Total 
  Amounts in Swiss francs
Balance as of January 1, 2023     1,153,483   269,511,610   64,620,223   (6,278,763)  (657,870)  26,426,243   (349,862,015)  4,912,911 
Net loss for the period     -   -   -   -   -   -   (7,699,391)  (7,699,391)
Other comprehensive loss for the period     -   -   -   -   (1,157)  (190,825)  -   (191,982)
Total comprehensive loss for the period     -   -   -   -   (1,157)  (190,825)  (7,699,391)  (7,891,373)
Issue of treasury shares  13  176,000   -   -   (176,000)  -   -   -   - 
Cost of treasury shares issuance     -   (16,823)  -   -   -   -   -   (16,823)
Sales under shelf registration  13  -   (920,069)  -   2,079,828   -   -   -   1,159,759 
Related costs of sales shelf-registration     -   (36,747)  -   -   -   -   -   (36,747)
Sale of pre-funded warrants  13  -   -   -   -   -   3,382,259   -   3,382,259 
Cost of pre-funded warrants sold     -   -   -   -   -   (136,326)  -   (136,326)
Exercise of pre-funded warrants  13  95,510   1,219,597   -   -   -   (1,314,807)  -   300 
Value of warrants and pre-funded warrants  13  -   (2,760,143)  -   -   -   2,760,143   -   - 
Value of share-based services  14  -   -   -   -   -   1,405,261   -   1,405,261 
Movement in treasury shares:  13                                
Net purchases under liquidity agreement     -   410   -   (3,151)  -   -   -   (2,741)
Sales agency agreement     -   (2,565,725)  -   3,742,506   -   -   -   1,176,781 
Costs under sale agency agreement     -   (8,826)  -   -   -   -   -   (8,826)
Balance as of September 30, 2023     1,424,993   264,423,284   64,620,223   (635,580)  (659,027)  32,331,948   (357,561,406)  3,944,435 
                                    
Balance as of January 1, 2024     1,843,545   266,194,689   64,620,223   (909,566)  (659,870)  30,474,686   (360,418,242)  1,145,465 
Net profit for the period     -   -   -   -   -   -   8,261,523   8,261,523 
Other comprehensive loss for the period     -   -   -   -   689   (201,511)  -   (200,822)
Total comprehensive profit for the period     -   -   -   -   689   (201,511)  8,261,523   8,060,701 
Cost of treasury shares issuance     -   (7,037)  -   -   -   -   -   (7,037)
Cost of pre-funded warrants exercised     -   (4,259)  -   -   -   -   -   (4,259)
Value of share-based services  14  -   -   -   -   -   1,629,773   -   1,629,773 
Movement in treasury shares:  13                                
Net sales under liquidity agreement     -   (2,434)  -   6,526   -   -   -   4,092 
Sales agency agreement     -   204,750   -   30,507   -   -   -   235,257 
Costs under sale agency agreement     -   (1,764)  -   -   -   -   -   (1,764)
Balance as of September 30, 2024     1,843,545   266,383,945   64,620,223   (872,533)  (659,181)  31,902,948   (352,156,719)  11,062,228 

 

The accompanying notes form an integral part of these consolidated financial statements.

 

5 

 

 

Addex Therapeutics │ Unaudited Interim Condensed Consolidated Financial Statements

 

Unaudited Interim Condensed Consolidated Statements of Changes in Equity

 

for the three-month period ended September 30, 2023

 

    Notes  Share
Capital		   Share
Premium		   Other
Equity		   Treasury
Shares
Reserve		   Foreign
Currency
Translation
Reserve		   Other
Reserves		   Accumulated
Deficit		   Total 
  Amounts in Swiss francs
Balance as of January 1, 2023     1,153,483   269,511,610   64,620,223   (6,278,763)  (657,870)  26,426,243   (349,862,015)  4,912,911 
Net loss for the period     -   -   -   -   -   -   (2,407,169)  (2,407,169)
Other comprehensive loss for the period     -   -   -   -   81   (30,641)  -   (30,560)
Total comprehensive loss for the period     -   -   -   -   81   (30,641)  (2,407,169)  (2,437,729)
Cost of shares issuance     -   (4,062)  -   -   -   -   -   (4,062)
Value of share-based  services  14  -   -   -   -   -   431,196   -   431,196 
Movement in treasury shares:  13                                
Net purchases under liquidity agreement     -   12,775   -   (11,818)  -   -   -   957 
Sales agency agreement     -   (2,565,725)  -   3,742,506   -   -   -   1,176,781 
Costs under sale agency agreement     -   (8,826)  -   -   -   -   -   (8,826)
Balance as of   March 31, 2023     1,153,483   266,945,772   64,620,223   (2,548,075)  (657,789)  26,826,798   (352,269,184)  4,071,228 
Net loss for the period     -   -   -   -   -   -   (2,675,152)  (2,675,152)
Other comprehensive loss for the period     -   -   -   -   (979)  (135,012)  -   (135,991)
Total comprehensive loss for the period     -   -   -   -   (979)  (135,012)  (2,675,152)  (2,811,143)
Issue of treasury shares     176,000   -   -   (176,000)  -   -   -   - 
Cost of treasury shares issuance     -   (12,761)  -   -   -   -   -   (12,761)
Sales under shelf registration  13  -   (920,069)  -   2,079,828   -   -   -   1,159,759 
Related costs of sales shelf-registration     -   (34,106)  -   -   -   -   -   (34,106)
Sale of pre-funded warrants  13  -   -   -   -   -   3,382,259   -   3,382,259 
Cost of pre-funded warrants sold     -   -   -   -   -   (118,117)  -   (118,117)
Exercise of pre-funded warrants  13  35,030   449,939   -   -   -   (484,930)  -   39 
Value of warrants and pre-funded warrants  13  -   (2,760,143)  -   -   -   2,760,143   -   - 
Value of share-based services  14  -   -   -   -   -   490,601   -   490,601 
Movement in treasury shares:  13                                
Net purchases under liquidity agreement     -   (10,592)  -   8,936   -   -   -   (1,656)
Balance as of June 30, 2023     1,364,513   263,658,040   64,620,223   (635,311)  (658,768)  32,721,742   (354,944,336)  6,126,103 
Net loss for the period     -   -   -   -   -   -   (2,617,070)  (2,617,070)
Other comprehensive loss for the period     -   -   -   -   (259)  (25,172)  -   (25,431)
Total comprehensive loss for the period     -   -   -   -   (259)  (25,172)  (2,617,070)  (2,642,501)
Related costs of sales shelf-registration     -   (2,641)  -   -   -   -   -   (2,641)
Cost of pre-funded warrants sold     -   -   -   -   -   (18,209)  -   (18,209)
Exercise of prefunded warrants  13  60,480   769,658   -   -   -   (829,877)  -   261 
Value of share-based services  14  -   -   -   -   -   483,464   -   483,464 
Movement in treasury shares:  13                                
Net purchases under liquidity agreement     -   (1,773)  -   (269)  -   -   -   (2,042)
Balance as of September 30, 2023     1,424,993   264,423,284   64,620,223   (635,580)  (659,027)  32,331,948   (357,561,406)  3,944,435 

 

The accompanying notes form an integral part of these consolidated financial statements.

 

6

 

 

Addex Therapeutics │ Unaudited Interim Condensed Consolidated Financial Statements

 

Unaudited Interim Condensed Consolidated Statements of Changes in Equity

 

for the three-month period ended September 30, 2024

 

   Notes Share
Capital		   Share
Premium		   Other
Equity		   Treasury
Shares Reserve		   Foreign
Currency
Translation
Reserve		   Other
Reserves		   Accumulated
Deficit		   Total 
  Amounts in Swiss francs
Balance as of January 1, 2024     1,843,545   266,194,689   64,620,223   (909,566)  (659,870)  30,474,686   (360,418,242)  1,145,465 
Net loss for the period     -   -   -   -   -   -   (3,087,139)  (3,087,139)
Other comprehensive loss for the period     -   -   -   -   1,128   (49,845)  -   (48,717)
Total comprehensive loss for the period     -   -   -   -   1,128   (49,845)  (3,087,139)  (3,135,856)
Cost of pre-funded warrants exercised     -   (3,647)  -   -   -   -   -   (3,647)
Value of share-based services  14  -   -   -   -   -   386,028   -   386,028 
Movement in treasury shares:  13                                
Net sales under liquidity agreement     -   (2,417)  -   3,947   -   -   -   1,530 
Sales agency agreement     -   204,750   -   30,507   -   -   -   235,257 
Costs under sale agency agreement     -   (1,764)  -   -   -   -   -   (1,764)
Balance as of March 31, 2024     1,843,545   266,391,611   64,620,223   (875,112)  (658,742)  30,810,869   (363,505,381)  (1,372,987)
Net profit for the period     -   -   -   -   -   -   12,878,634   12,878,634 
Other comprehensive loss for the period     -   -   -   -   (143)  (52,258)  -   (52,401)
Total comprehensive profit for the period     -   -   -   -   (143)  (52,258)  12,878,634   12,826,233 
Cost of treasury shares issuance     -   (7,037)  -   -   -   -   -   (7,037)
Cost of pre-funded warrants exercised     -   (612)  -   -   -   -   -   (612)
Value of share-based services  14  -   -   -   -   -   1,205,295   -   1,205,295 
Movement in treasury shares:  13                                
Net sales under liquidity agreement     -   157   -   253   -   -   -   410 
Balance as of June 30, 2024     1,843,545   266,384,119   64,620,223   (874,859)  (658,885)  31,963,906   (350,626,747)  12,651,302 
Net profit for the period     -   -   -   -   -   -   (1,529,972)  (1,529,972)
Other comprehensive loss for the period     -   -   -   -   (296)  (99,408)  -   (99,704)
Total comprehensive profit for the period     -   -   -   -   (296)  (99,408)  (1,529,972)  (1,629,676)
Value of share-based services  14  -   -   -   -   -   38,450   -   38,450 
Movement in treasury Shares:  13                                
Net sales under liquidity agreement     -   (174)  -   2,326   -   -   -   2,152 
Balance as of September 30, 2024     1,843,545   266,383,945   64,620,223   (872,533)  (659,181)  31,902,948   (352,156,719)  11,062,228 

 

The accompanying notes form an integral part of these consolidated financial statements.

 

7

 

 

Addex Therapeutics │ Unaudited Interim Condensed Consolidated Financial Statements

 

Unaudited Interim Condensed Consolidated Statements of Cash Flows

 

for the nine-month periods ended September 30, 2024 and 2023

 

      For the nine months ended
September 30,		 
   Notes  2024   2023 
            
      Amounts in Swiss francs 
Net profit / (loss) for the period       8,261,523    (7,699,391)
Adjustments for:              
Net gain on Neurosterix Transaction   21   (13,959,500)   - 
Value of share-based services   14/21   471,704    1,405,261 
Post-employment benefits   15/21   (29,331)   (45,057)
Share of net loss of associates   22   1,405,682    - 
Depreciation   8/21   236,317    226,567 
Net gain related to lease modifications       (2,270)   (318)
Net finance cost / (gain)       (67,386)   112,172 
Decrease / increase in other financial assets   7/21   (4,098)   2,739 
Decrease / (increase) in trade and other receivables   7/21   (371,386)   232,609 
Decrease / (increase) in contract asset   7/21   4,405    (7,658)
Increase in prepayments   7/21   (190,970)   (344,415)
Increase in other current assets   7/21   (5,000)   - 
Decrease in payables and accruals   12/21   (1,061,287)   (1,251,897)
Decrease in deferred income       (38,401)   - 
Net cash used in operating activities       (5,349,998)   (7,369,388)
               
Cash flows from / (used in) investing activities              
Cash received from Neurosterix Transaction   21   5,119,754    - 
Legal fees paid for Neurosterix Transaction   21   (457,365)   - 
Purchase of property, plant and equipment   9   (1,273)   (5,637)
Net cash from / (used in) investing activities       4,661,116    (5,637)
               
Cash flows from financing activities              
Proceeds from the sale of treasury shares – shelf registration   13   -    1,159,759 
Costs paid on sale of treasury shares – shelf registration       (24,018)   (35,923)
Proceeds from the sale or exercise of pre-funded warrants   13   -    3,396,834 
Costs paid on sale or exercise of pre-funded warrants       (36,457)   (134,175)
Sales under sale agency agreement & liquidity agreement movements   13   239,349    1,174,040 
Costs paid on sale of treasury shares under sale agency agreement       (1,764)   (8,826)
Cost paid on issue of treasury shares   13   -    (53,600)
Principal element of lease payment       (71,915)   (212,742)
Interest received   20   9,180    50,833 
Interest paid   20   (7,733)   (13,251)
Net cash from financing activities       106,642    5,322,949 
               
Decrease in cash and cash equivalents       (582,240)   (2,052,076)
               
Cash and cash equivalents at the beginning of the period   6   3,865,481    6,957,086 
Exchange difference on cash and cash equivalents       65,939    (150,903)
               
Cash and cash equivalents at the end of the period   6   3,349,180    4,754,107 

 

During the nine-month period ended September 30, 2024, the Group reported a net gain of CHF 13.96 million of which CHF 8.87 million relates to non-cash items including CHF 9.43 million for the fair value of its 20 % participation in Neurosterix US Holdings LLC and CHF 0.2 million for the fair value of the service agreement provided at zero cost partially offset by the accelerated vesting of equity incentive units of employees transferred to Neurosterix Pharma Sàrl amounting to CHF 1.2 million (note 21). During the same period, the share of the net loss of associates amounted to CHF 1.4 million.

 

The accompanying notes form an integral part of these consolidated financial statements.

 

8

 

 

Unaudited Notes to the Interim Condensed Consolidated Financial Statements

 

Addex Therapeutics │ Unaudited Interim Condensed Consolidated Financial Statements │Notes

 

for the nine-month period ended September 30, 2024

 

(Amounts in Swiss francs)

 

1. General information

 

Addex Therapeutics Ltd (the “Company”) and its subsidiaries (together, the “Group”) are a clinical stage biopharmaceutical company focused on developing a portfolio of novel small molecule allosteric modulators for neurological disorders.

 

The Company is a Swiss stockholding corporation domiciled c/o Addex Pharma SA, Chemin des Aulx 12, CH 1228 Plan-les-Ouates, Geneva, Switzerland and the parent company of Addex Pharma SA, Addex Pharmaceuticals France SAS, Neurosterix SA and Addex Pharmaceuticals Inc. Addex Therapeutics also owns a 20% equity interest in Neurosterix US Holdings LLC, USA. Neurosterix US Holdings LLC fully owns directly Neurosterix Swiss Holdings AG, Switzerland and indirectly Neurosterix Pharma Sàrl whose principal place of business is Chemin des Mines 9, CH 1202 Geneva, Switzerland.

 

The Groups principal place of business is Chemin des Mines 9, CH 1202 Geneva, Switzerland. Its registered shares are traded at the SIX Swiss Exchange, under the ticker symbol ADXN and its American Depositary Shares (ADSs) on the Nasdaq Stock Market under the symbol “ADXN”. ADSs represents shares that continue to be admitted to trading on SIX Swiss Exchange.

 

These interim condensed consolidated financial statements have been approved for issuance by the Board of Directors on November 21, 2024.

 

2. Basis of preparation

 

These interim condensed consolidated financial statements for the nine-month period ended September 30, 2024, have been prepared under the historic cost convention and in accordance with IAS 34 “Interim Financial Reporting” and are presented in a format consistent with the consolidated financial statements under IAS 1 “Presentation of Financial Statements”. However, they do not include all of the notes that would be required in a complete set of financial statements. Thus, this interim financial report should be read in conjunction with the consolidated financial statements for the year ended December 31, 2023.

 

Interim financial results are not necessarily indicative of results anticipated for the full year. The preparation of these unaudited interim condensed consolidated financial statements made in accordance with IAS 34 requires the use of estimates and assumptions that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities at the date of the financial statements and the reported amounts of revenues and expenses during the reporting period. Although these estimates are based on management’s best knowledge of current events and actions, actual results ultimately may differ from those estimates. The areas involving a higher degree of judgment which are significant to the interim condensed consolidated financial statements are disclosed in note 4 to the consolidated financial statements for the year ended December 31, 2023.

 

A number of new or amended standards and interpretations became applicable for financial reporting periods beginning on or after January 1, 2024. Of the latter, the Group noted the publication of IFRS S1 (General requirement for disclosure of sustainability-related financial information) and IFRS S2 (climate – related Disclosures). The Group concluded that those new IFRS standards were not relevant as the Group did not opt for the publication of a sustainability report in accordance with Six Swiss Exchange listing rules.

 

There are other new standards, amendments and interpretations which have been deemed by the Group as currently not relevant, hence are not listed or discussed further here.

 

Due to rounding, numbers presented throughout these interim condensed consolidated financial statements may not add up precisely to the totals provided. All ratios and variances are calculated using the underlying amounts rather than the presented rounded amounts.

 

Where necessary, comparative figures have been revised to conform with the current year 2024 presentation. In particular, we re-presented the unaudited interim condensed consolidated statements of profit or loss and comprehensive income or loss for the three-month and nine-month periods ended September 30, 2023, in order to reclass discontinued operations in accordance with IFRS 5 (note 21). In addition, the ADS numbers previously disclosed have been amended following the change in ADS ratio executed on October 23, 2023, from one ADS to six shares to a new ratio of one ADS to one hundred and twenty shares. The ADS ratio change had the same effect as a one to twenty ADS reverse split and except as otherwise indicated, all information in these consolidated financial statements gives retroactive effect to the ADS Ratio Change.

 

9

 

 

Addex Therapeutics │ Unaudited Interim Condensed Consolidated Financial Statements │Notes

 

3. Material accounting estimates and judgments

 

The Group makes estimates and assumptions concerning the future. These estimates and judgments are continually evaluated and are based on historical experience and other factors, including expectations of future events that are believed to be reasonable under the circumstances. The resulting accounting estimates will, by definition, seldom equal the related actual results. The estimates and assumptions that have a significant risk of causing a material adjustment to the carrying amounts of assets and liabilities or may have had a significant impact on the reported results are disclosed below:

 

Going concern

 

The Group’s accounts are prepared on a going concern basis. To date, the Group has financed its cash requirements primarily from share issuances, licensing certain of its research and development stage products and selling its allosteric modulator drug discovery technology platform with a portfolio of preclinical programs. The Group is a development - stage enterprise and is exposed to all the risks inherent in establishing a business. The Group expects that its existing cash and cash equivalents, at the issuance date of these unaudited consolidated financial statements will be sufficient to fund its operations and meet all of its obligations as they fall due, through 2026. The future viability of the Group is dependent on its ability to raise additional capital through public or private financings or collaboration agreements to finance its future operations, which may be delayed due to reasons outside of the Group’s control including health pandemics and geopolitical risks. The sale of additional equity may dilute existing shareholders. The inability to obtain funding, as and when needed, would have a negative impact on the Group’s financial condition and ability to pursue its business strategies. If the Group is unable to obtain the required funding to run its operations and to develop and commercialize its product candidates, the Group could be forced to delay, reduce or stop some or all of its research and development programs to ensure it remains solvent. Management continues to explore options to obtain additional funding, including through collaborations with third parties related to the future potential development and/or commercialization of its product candidates. However, there is no assurance that the Group will be successful in raising funds, closing collaboration agreements, obtaining sufficient funding on terms acceptable to the Group, or if at all, which could have a material adverse effect on the Group’s business, results of operations and financial condition.

 

The Business of the Group could be adversely affected by health pandemics and geopolitical risks

 

The business of the Group could be adversely affected by health epidemics and geopolitical risks in regions where the Group or partners have concentrations of clinical trial sites or other business operations and could cause significant disruption in the operations of third-party manufacturers and CROs upon whom the Group or partners rely. Health pandemics may pose the risk that the Group, employees, contractors, collaborators, and partners may be prevented from conducting certain pre-clinical tests, clinical trials or other business activities for an indefinite period of time, including due to travel restrictions, quarantines, “stay-at-home” and “shelter-in-place” orders or shutdowns that have been or may in the future be requested or mandated by governmental authorities. For example, the COVID-19 pandemic has impacted the business of the Group and clinical trials led by the Group or partners, including as a result of delays or difficulties in clinical site initiation, difficulties in recruiting and retaining clinical site investigators and clinical site staff and interruption of the clinical supply chain or key clinical trial activities, such as clinical trial site monitoring, and supply chain interruptions caused by restrictions for the supply of materials for drug candidates or other materials necessary to manufacture product to conduct clinical and preclinical tests. Geopolitical risks such as Russia-Ukraine war or Middle East conflict may create global security concerns including the possibility of an expanded regional or global conflict and potential ramifications such as disruption of the supply chain including research and development activities being conducted by the Group and its strategic partners. Delays in research and development activities of the Group and its partners could increase associated costs and, depending upon the duration of any delays, require the Group and its partners to find alternative suppliers at additional expense. In addition, Russia-Ukraine war has had significant ramifications on global financial markets, which may adversely impact the ability of the Group to raise capital on favorable terms or at all.

 

Discontinued operations related to the Neurosterix Transaction

 

On April 2, 2024, the Group sold a part of its business constituting its allosteric modulator drug discovery technology platform and a portfolio of preclinical programs (note 21). As a consequence, the Group recognized discontinued operations in the statements of profit or loss under “net profit or loss from discontinued operations” for the three-month and nine- month periods ended September 30, 2024 and 2023 respectively, in accordance with IFRS 5. The Group identified as well, cash flows from discontinued operations for the nine-month period ended September 30, 2024 and 2023, respectively (note 21). The identification of discontinued operations may require some degree of judgement.

 

Investments accounted for using the equity method

 

The Group received an equity interest of 20% in Neurosterix US Holdings LLC as part of the Neurosterix Transaction. The initial recognition of the investment has been accounted at a fair value based on a financial valuation of Neurosterix’s Group. This carrying amount is going to be increased or decreased to recognize the share of profit or loss of Neurosterix’s Group and tested for impairment whenever events or changes in circumstances indicate that it may not be recoverable.

 

10

 

 

Addex Therapeutics │ Unaudited Interim Condensed Consolidated Financial Statements │Notes

 

Revenue recognition

 

Revenue is primarily from fees related to licenses, milestones and research services. Given the complexity of the relevant agreements, judgements are required to identify distinct performance obligations, allocate the transaction price to these performance obligations and determine when the performance obligations are met. In particular, the Group’s judgement over the estimated stand-alone selling price which is used to allocate the transaction price to the performance obligations is disclosed in note 16.

 

Grants

 

Grants are recorded at their fair value when there is reasonable assurance that they will be received and recognized as income when the Group has satisfied the underlying grant conditions. In certain circumstances, grant income may be recognized before explicit grantor acknowledgement that the conditions have been met.

 

Accrued research and development costs

 

The Group records accrued expenses for estimated costs of research and development activities conducted by third party service providers. The Group records accrued expenses for estimated costs of research and development activities based upon the estimated amount of services provided, but not yet invoiced, and these costs are included in accrued expenses on the balance sheets and within research and development expenses in the statements of profit or loss. These costs are a significant component of research and development expenses. Accrued expenses for these costs are recorded based on the estimated amount of work completed in accordance with agreements established with these third parties. Due to the nature of estimates, the Group may be required to make changes to the estimates after a reporting period as it becomes aware of additional information about the status or conduct of its research activities.

 

Research and development costs

 

The Group recognizes expenditure incurred in carrying out its research and development activities, including development supplies, until it becomes probable that future economic benefits will flow to the Group, which results in recognizing such costs as intangible assets, involving a certain degree of judgement. Currently, such development supplies are associated with preclinical and clinical trials of specific products that have not demonstrated technical feasibility.

 

Share-based compensation

 

The Group recognizes an expense for share-based compensation based on the valuation of equity incentive units using the Black-Scholes valuation model. A number of assumptions related to the volatility of the underlying shares and to the risk-free rate are made in this model. Should the assumptions and estimates underlying the fair value of these instruments vary significantly from management’s estimates, then the share-based compensation expense would be materially different from the amounts recognized.

 

Equity instruments

 

The Group records the prefunded warrants sold to investors and the warrants granted to investors at fair value calculated using the Black-Scholes valuation model.

 

Pension obligations

 

The present value of the pension obligations is calculated by an independent actuary and depends on a number of assumptions that are determined on an actuarial basis such as discount rates, future salary and pension increases, and mortality rates. Any changes in these assumptions will impact the carrying amount of pension obligations. The Group determines the appropriate discount rate at the end of each period. This is the interest rate that should be used to determine the present value of estimated future cash outflows expected to be required to settle the pension obligations. In determining the appropriate discount rate, the Group considers the interest rates of high-quality corporate bonds that are denominated in the currency in which the benefits will be paid, and that have terms to maturity approximating the terms of the related pension liability. Other key assumptions for pension obligations are based in part on current market conditions.

 

4. Interim measurement note

 

Seasonality of the business: The business is not subject to any seasonality, but expenses and corresponding revenue are largely determined by the phase of the respective projects, particularly with regard to external research and development expenditures.

 

Costs: Costs that incur unevenly during the financial year are anticipated or deferred in the interim report only if it would also be appropriate to anticipate or defer such costs at the end of the financial year.

 

11

 

 

Addex Therapeutics │ Unaudited Interim Condensed Consolidated Financial Statements │Notes

 

5. Segment reporting

 

Management has identified one single operating segment, related to the discovery, development and commercialization of small-molecule pharmaceutical products.

 

Information about products, services and major customers

 

External income of the Group for the three-month and nine-month periods ended September 30, 2024 and 2023 is derived from the business of discovery, development and commercialization of pharmaceutical products. Income was earned from rendering of research services to a pharmaceutical company.

 

Information about geographical areas

 

External income is exclusively recorded in the Swiss operating company.

 

Analysis of revenue from contract with customer and other income by nature is detailed as follows:

 

   For the three months
ended September 30,		   For the nine months
ended September 30,		 
   2024   2023*   2024   2023* 
Collaborative research funding   53,837    327,733    402,594    1,459,502 
Other service income   4,510    1,485    5,940    3,740 
Total   58,347    329,218    408,534    1,463,242 

 

Analysis of revenue from contract with customer and other income by major counterparties is detailed as follows:

 

   For the three months
ended September 30,		   For the nine months
ended September 30,		 
   2024   2023*   2024   2023* 
Indivior PLC   53,837    327,733    402,594    1,459,502 
Other counterparties   4,510    1,485    5,940    3,740 
Total   58,347    329,218    408,534    1,463,242 

 

For more detail, refer to note 16, “Revenue from contract with customer” and note 17 “Other income”.

 

The geographical allocation of long-lived assets is detailed as follows:

 

    September 30, 2024   December 31, 2023 
Switzerland   8,095,951   406,946 
France   338   334 
Total   8,096,289   407,280 

 

The geographical analysis of operating costs is as follows:

 

   For the three months
ended September 30,		   For the nine months
ended September 30,		 
   2024   2023*   2024   2023* 
Switzerland   652,341    1,074,865    2,683,805    2,965,382 
United States of America   26,709    2,432    30,726    7,706 
France   1,496    1,159    3,610    3,230 
Total operating costs (note 18)   680,546    1,078,456    2,718,141    2,976,318 

 

The capital expenditure during the nine-months period ended September 30, 2024 is CHF 1,273 (CHF 5,637 for the nine-month period ended September 30, 2023).

 

12

 

 

Addex Therapeutics │ Unaudited Interim Condensed Consolidated Financial Statements │Notes

 

6. Cash and cash equivalents

 

   September 30, 2024   December 31, 2023 
Cash at bank and on hand  3,349,180   3,865,481 
Total cash and cash equivalents  3,349,180   3,865,481 

 

Split by currency:

 

    September 30, 2024   December 31, 2023 
CHF   80.87%  39.88%
USD   13.70%  56.22%
EUR   3.54%  3.03%
GBP   1.89%  0.87%
Total   100.00%  100.00%

 

The Group invests its cash balances into a variety of current accounts mainly with two Swiss banks whose external credit rating is P-1/A-1.

 

All cash and cash equivalents were held either at banks or on hand as of September 30, 2024 and December 31, 2023.

 

7. Other current assets

 

   September 30, 2024   December 31, 2023 
Other financial assets  4,946   848 
Trade and other receivables  480,006   110,361 
Contract asset (Indivior PLC)  36,502   40,907 
Prepayments  196,335   217,008 
Other current assets  5,000   - 
Total other current assets  722,789   369,124 

 

Total other current assets increased by CHF 0.4 million as of September 30, 2024 compared to December 31, 2023, primarily due to increased trade and other receivables as retirement benefits of employees transferred to Neurosterix Pharma Sàrl are expected to be recovered in the short term. The Group applies the IFRS 9 simplified approach to measuring expected credit losses (“ECL”), which uses a lifetime expected loss allowance for all contract assets, trade receivables and other receivables. The Group has considered that the contract asset, trade receivables and other receivables have a low risk of default based on historic loss rates and forward-looking information on macroeconomic factors affecting the ability of the third parties to settle invoices. As a result, expected loss allowance has been deemed as nil as of September 30, 2024 and December 31, 2023.

 

8. Right-of-use assets

 

Year ended December 31, 2023  Properties   Equipment   Total 
Opening net book amount   353,097    4,516    357,613 
Depreciation charge   (277,885)   (2,708)   (280,593)
Effect of lease modifications   253,312    -    253,312 
Closing net book amount   328,524    1,808    330,332 

 

As of December 31, 2023  Properties   Equipment   Total 
Cost   1,725,162    13,542    1,738,704 
Accumulated depreciation   (1,396,638)   (11,734)   (1,408,372)
Net book value   328,524    1,808    330,332 

 

Period ended September 30, 2024  Properties   Equipment   Total 
Opening net book amount   328,524    1,808    330,332 
Depreciation charge   (71,325)   (677)   (72,002)
Effect of lease modifications   23,940    -    23,940 
Disposals   (7,408)   -    (7,408)
Assets transferred to Neurosterix Pharma Sàrl   (230,141)   (1,131)   (231,272)
Closing net book amount   43,590    -    43,590 

 

13

 

 

Addex Therapeutics │ Unaudited Interim Condensed Consolidated Financial Statements │Notes

 

As of September 30, 2024  Properties   Equipment   Total 
Cost   111,642    -    111,642 
Accumulated depreciation   (68,052)   -    (68,052)
Net book value   43,590    -    43,590 

 

The gross value of the right of use assets decreased by CHF 1,627,062 between the periods ended December 31, 2023, and September 30, 2024, primarily due to the transfer of assets to Neurosterix Pharma Sàrl during the second quarter of 2024.

 

9. Property, plant and equipment

 

Year ended December 31, 2023  Equipment   Furniture &
fixtures		   Chemical
library		   Total 
Opening net book amount   41,121    -    -    41,121 
Additions   6,842    -    -    6,842 
Depreciation charge   (25,359)   -    -    (25,359)
Closing net book amount   22,604    -    -    22,604 

 

As of December 31, 2023  Equipment   Furniture &
fixtures		   Chemical
library		   Total 
Cost   1,721,251    7,564    1,207,165    2,935,980 
Accumulated depreciation   (1,698,647)   (7,564)   (1,207,165)   (2,913,376)
Net book value   22,604    -    -    22,604 

 

Period ended September 30, 2024  Equipment   Furniture &
fixtures		   Chemical
library		   Total 
Opening net book amount   22,604    -    -    22,604 
Additions   1,273              1,273 
Depreciation charge   (3,652)   -    -    (3,652)
Assets transferred to Neurosterix Pharma Sàrl   (18,987)   -    -    (18,987)
Closing net book amount   1,238    -    -    1,238 

 

As of September 30, 2024  Equipment   Furniture &
fixtures		   Chemical
library		   Total 
Cost   84,775    -    -    84,775 
Accumulated depreciation   (83,537)   -    -    (83,537)
Net book value   1,238    -    -    1,238 

 

The gross value of property, plant and equipment decreased by CHF 2,851,205 between the periods ended December 31, 2023, and September 30, 2024, primarily due to the transfer of fixed assets to Neurosterix Pharma Sàrl for a gross amount of CHF 2,596,458 and disposals amounting to CHF 256,020.

 

10. Intangible assets

 

Period ended September 30, 2024  Service
agreement		   Total 
Opening net book amount   -    - 
Additions   182,348    182,348 
Depreciation charge   (160,663)   (160,663)
Closing net book amount   21,685    21,685 

 

As of September 30, 2024  Service
agreement		   Total 
Cost   182,348    182,348 
Accumulated depreciation   (160,663)   (160,663)
Net book value   21,685    21,685 

 

The service agreement relates to staff and infrastructure provided by Neurosterix Pharma Sàrl at zero cost in accordance with the Neurosterix Transaction (note 21). The depreciation charge is recognized at the rate at which these services are provided.

 

14

 

 

Addex Therapeutics │ Unaudited Interim Condensed Consolidated Financial Statements │Notes

 

11. Non-current financial assets

 

   September 30, 2024   December 31, 2023 
Security rental deposits   7,058    54,344 
Total non-current financial assets   7,058    54,344 

 

12. Payables and accruals

 

   September 30, 2024   December 31, 2023 
Trade payables   325,782    984,384 
Social security and other taxes   75,108    164,609 
Accrued expenses   479,459    1,235,357 
Total payables and accruals   880,349    2,384,350 

 

All payables mature within 3 months. Accrued expenses and trade payables primarily relate to R&D services from contract research organizations, consultants and professional fees. The total amount of payables and accruals decreased by CHF 1.5 million as of September 30, 2024 compared to December 31, 2023 mainly due to the sale of a part of our business on April 2, 2024 (note 21). The carrying amounts of payables do not materially differ from their fair values, due to their short-term nature.

 

13. Share capital

 

   Number of shares 
   Common
shares		   Treasury
shares		   Total 
Balance as of January 1, 2023   115,348,311    (38,214,291)   77,134,020 
Issue of shares – treasury shares   17,600,000    (17,600,000)   - 
Sale of shares under shelf registration   -    7,999,998    7,999,998 
Exercise of pre-funded warrants (1)   9,550,950    -    9,550,950 
Sale of shares under sale agency agreement   -    3,742,506    3,742,506 
Net purchase of shares under liquidity agreement   -    (50,472)   (50,472)
Acquisition of shares forfeited from DSPPP   -    (7,311)   (7,311)
Balance as of September 30, 2023   142,499,261    (44,129,570)   98,369,691 
Shares reclassed as treasury shares under IFRS 2   -    (17,431,572)   (17,431,572)
Balance as of September 30, 2023 IFRS 2   142,499,261    (61,561,142)   80,938,119 

 

(1) In accordance with Swiss law, the issuance of 9,550,950 new shares through the exercise of pre-funded warrants during the nine-month period ended September 30, 2023 has been registered in the trade register on December 13, 2023. As of September 30, 2023, the amount of the share capital as registered in the trade register is CHF 1,329,483.11 divided into 132,948,311 shares.

 

   Number of shares 
   Common
shares		   Treasury
shares		   Total 
Balance as of January 1, 2024 (1)   184,354,496    (59,159,103)   125,195,393 
Sale of shares under sale agency agreement   -    3,050,665    3,050,665 
Net sale of shares under liquidity agreement   -    36,449    36,449 
Acquisition of shares forfeited from DSPPP   -    (8,539)   (8,539)
Balance as of September 30, 2024   184,354,496    (56,080,528)   128,273,968 
Shares reclassed as treasury shares under IFRS 2   -    (29,950,268)   (29,950,268)
Balance as of September 30, 2024 IFRS 2   184,354,496    (86,030,796)   98,323,700 

 

(1) In accordance with Swiss law, the issuance of 6,120,000 new shares through the exercise of pre-funded warrants from December 12, 2023 to December 31, 2023, have been registered in the commercial register on February 20, 2024. As of January 1, 2024, the amount of the share capital as registered in the commercial register is CHF 1,782,344.96 divided into 178,234,496 shares.

 

As of September 30, 2024, 128,273,968 shares were outstanding excluding 56,080,528 treasury shares directly held by Addex Pharma SA and including 29,950,268 outstanding shares benefiting from our DSPPP, considered as treasury shares under IFRS 2 (note 14). As of September 30, 2023, 98,369,691 shares were outstanding excluding 44,129,570 treasury shares directly held by Addex Pharma SA and including 17,431,572 outstanding shares benefiting from our DSPPP, considered as treasury shares under IFRS 2. All shares have a nominal value of CHF 0.01.

 

15

 

 

Addex Therapeutics │ Unaudited Interim Condensed Consolidated Financial Statements │Notes

 

The Group maintains a liquidity agreement with Kepler Cheuvreux (“Kepler”). Under the agreement, the Group has provided Kepler with cash and shares to enable them to buy and sell the Company’s shares. As of September 30, 2024, 135,623 (December 31, 2023: 172,072) treasury shares are recorded under this agreement in the treasury share reserve and CHF 4,946 (December 31, 2023: CHF 848) is recorded in other financial assets.

 

During the nine-month period ended September 30, 2024, the Group sold 3,050,665 treasury shares under the sale agency agreement with Kepler Cheuvreux at an average price of CHF 0.077 per share for gross proceeds of CHF 235,257 (during the nine-month period ended September 30, 2023, the Group sold 3,742,506 treasury shares at an average price of CHF 0.31 per share for gross proceeds of CHF 1,176,781).

 

On February 20, 2024, in accordance with Swiss law, the company registered in the commercial register 6,120,000 new shares issued out of conditional capital from December 12, 2023 to December 31, 2023 following the exercise of pre-funded warrants granted to one institutional investor on April 3, 2023.

 

On June 14, 2023, the Company increased its capital from CHF 1,153,483 to CHF 1,329,483 through the issuance of 17,600,000 new shares from its capital band to its 100% owned subsidiary, Addex Pharma SA, at the nominal value of CHF 0.01. These shares are held as treasury shares.

 

On April 3, 2023, the Group entered into a securities purchase agreement with an institutional investor. The Group sold 7,999,998 treasury shares in the form of ADSs at a price of USD 0.16 (CHF 0.14) per share equivalent to USD 19.00 per ADS (CHF 17.20 per ADS) and 23,578,950 pre-funded warrant shares in the form of ADSs at a price of USD 0.16 (CHF 0.14 per share) equivalent to USD 18.80 (CHF 17.02) per ADS. From June 4, 2023 to September 30, 2023, the institutional investor exercised 9,550,950 pre-funded warrants in a form of ADSs allowed by the issuance of 9,550,950 new shares through our listed conditional capital. The new issued shares have been registered in the trade register on December 13, 2023 in accordance with Swiss corporate law. The remaining 14,028,000 pre-funded warrants in a form of ADSs have been exercised during the fourth quarter of 2023. The total gross proceeds from the offering amounted to USD 5.0 million (CHF 4.5 million) and directly attributable share offering costs of CHF 0.2 million were recorded as a deduction in equity. In addition, the Group granted the institutional investor, 31,578,948 warrant shares exercisable in the form of ADSs with an exercise price of USD 0.17 (CHF 0.15) per share equivalent to USD 20.00 (CHF 18.11) per ADS and an exercise period expiring on April 5, 2028. The fair value of the warrant shares amounts to CHF 1.78 million and has been recorded in equity as a cost of the offering. The Group also reduced the price to USD 0.17 (CHF 0.15) per share equivalent to USD 20.00 (CHF 18.11) per ADS and extended the exercise period to April 5, 2028 of 9,230,772 warrant shares exercisable in the form of ADSs and 15,000,000 warrant shares exercisable in the form of ADSs granted in the securities purchase agreement signed on December 16, 2021 and July 22, 2022, respectively. The amendments to the exercise conditions resulted in an increase in the total fair value of CHF 0.96 million that has been recorded in equity as a cost of the offering.

 

14. Share-based compensation

 

The total share-based compensation expense for equity incentive units recognized as continuing operating costs in the statement of profit or loss for the three-month and nine-month periods ended September 30, 2024 amounted to CHF 38,450, and CHF 144,023 respectively (CHF 77,543 and CHF 218,865 for the three-month and nine-month periods ended September 30, 2023).

 

The total share-based compensation expense for equity incentive units recognized as discontinued operating costs in the statement of profit or loss under “net profit or loss from discontinued operations” for the nine-month periods ended September 30, 2023 and 2024 amounted to CHF 1,186,396 and CHF 1,485,750 respectively (note 21).

 

As of September 30, 2024, 8,006,791 options were outstanding (December 31, 2023: 1,570,346). On January 8, 2024, the Group granted 6,439,124 options at an exercise price of CHF 0.05 with vesting over 4 years and a 10-year exercise period.

 

As of September 30, 2024, 29,950,268 shares benefiting from our Deferred Strike Price Payment Plan (DSPPP) were outstanding (respectively 29,958,807 shares as of December 31, 2023). All the shares benefiting from our DSPPP have been recorded as treasury shares in accordance with IFRS 2 (note 13).

 

16

 

 

Addex Therapeutics │ Unaudited Interim Condensed Consolidated Financial Statements │Notes

 

15. Retirement benefits obligations

 

The amounts recognized in the statement of profit or loss are as follows:

 

   For the three months
ended September 30,		   For the nine months
ended September 30,		 
   2024   2023*   2024   2023* 
Current service cost   (3,206)   (3,366)   (9,560)   (10,064)
Past service cost   -    -    1,070    1,348 
Interest cost   (7,212)   (1,964)   (16,298)   (6,662)
Interest income   7,028    1,872    15,690    6,404 
Company pension amount (note 19)   (3,390)   (3,458)   (9,098)   (8,974)

 

The Group’s pension costs recognized as continuing operating costs in the statement of profit or loss for the three-month and nine-month periods ended September 30, 2024, amounted to CHF 3,390 and CHF 9,098, respectively (CHF 3,458 and CHF 8,974 for the three-month and nine-month periods ended September 30, 2023).

 

The Group recognized a pension gain as discontinued operations in the statement of profit or loss under “net profit or loss from discontinued operations” for the nine-month period ended September 30, 2024, amounting to CHF 391,298 primarily due to a reduced number of employees generating a positive past service cost. During the same period ended September 30, 2023, a cost of CHF 170,169 was recognized (note 21).

 

The amounts recognized in the balance sheet are determined as follows:

 

   September 30, 2024   December 31, 2023 
Defined benefit obligation   (2,109,786)   (9,138,045)
Fair value of plan assets   1,927,872    8,694,521 
Retirement benefit obligation   (181,914)   (443,524)

 

Retirement benefit obligation decreased by CHF 0.3 million as of September 30, 2024 compared to December 31, 2023 primarily due to a reduced number of employees.

 

16. Revenue from contract with customer

 

License & research agreement with Indivior PLC

 

On January 2, 2018, the Group entered into an agreement with Indivior for the discovery, development and commercialization of novel GABAB PAM compounds for the treatment of addiction and other CNS diseases. This agreement included the selected clinical candidate, ADX71441. In addition, Indivior agreed to fund a research program at the Group to discover novel GABAB PAM compounds.

 

The contract contains two distinct material promises and performance obligations: (1) the selected compound ADX71441 which falls within the definition of a licensed compound, whose rights of use and benefits thereon was transferred in January 2018 and, (2) the research services to be conducted by the Group and funded by Indivior to discover novel GABAB PAM compounds for clinical development that may be discovered over the research term of the agreement and selected by Indivior.

 

Indivior has sole responsibility, including funding liability, for development of selected compounds under the agreement through preclinical and clinical trials, as well as registration procedures and commercialization, if any, worldwide. Indivior has the right to design development programs for selected compounds under the agreement. Through the Group’s participation in a joint development committee, the Group reviews, in an advisory capacity, any development programs designed by Indivior. However, Indivior has authority over all aspects of the development of such selected compounds.

 

Under terms of the agreement, the Group granted Indivior an exclusive license to use relevant patents and know-how in relation to the development and commercialization of product candidates selected by Indivior. Subject to agreed conditions, the Group and Indivior jointly own all intellectual property rights that are jointly developed and the Group or Indivior individually own all intellectual property rights that the Group or Indivior develop individually. The Group has retained the right to select compounds from the research program for further development in areas outside the interest of Indivior including chronic cough. Under certain conditions, but subject to certain consequences, Indivior may terminate the agreement.

 

In January 2018, the Group received, under the terms of the agreement, a non-refundable upfront fee of USD 5.0 million for the right to use the clinical candidate, ADX71441, including all materials and know-how related to this clinical candidate. In addition, the Group is eligible for payments on successful achievement of pre-specified clinical, regulatory and commercial milestones totaling USD 330 million and royalties on net sales of mid-single digits to low double-digits.

 

17

 

 

Addex Therapeutics │ Unaudited Interim Condensed Consolidated Financial Statements │Notes

 

On February 14, 2019, Indivior terminated the development of their selected compound, ADX71441. Separately, Indivior funds research at the Group, based on a research plan to be mutually agreed between the parties, to discover novel GABAB PAM compounds. These future novel GABAB PAM compounds, if selected by Indivior, become licensed compounds. The Group agreed with Indivior to an initial research term and duration of two years with a funding of USD 4 million over the period for the Group’s R&D costs incurred, that can be extended by twelve-month increments. R&D costs are calculated based on the costs incurred in accordance with the contract. Following Indivior’s selection of one newly identified compound, the Group has the right to also select one additional newly identified compound. The Group is responsible for the funding of all development and commercialization costs of its selected compounds and Indivior has no rights to the Group’s selected compounds. The initial two-year research term was expected to run from May 2018 to April 2020. In 2019, Indivior agreed to an additional research funding of USD 1.6 million, for the research period. On October 30, 2020, the research term was extended until June 30, 2021 and Indivior agreed to additional research funding of USD 2.8 million. Effective May 1, 2021, the research term was extended until July 31, 2022 and Indivior agreed additional research funding of CHF 3.7 million, of which CHF 2.7 million was paid to the Group and CHF 1.0 million paid directly by Indivior to third party suppliers that are supporting the funded research program. In August 2022, the research agreement was extended until March 31, 2023 and Indivior agreed to additional research funding of CHF 0.85 million. The reserved indications, where Addex retains exclusive rights to develop its own independent GABAB PAM program, have also been expanded to include chronic cough. Effective November 1, 2022, the research term was extended until June 30, 2023 and Indivior agreed to additional research funding of CHF 0.95 million. Effective July 1, 2023, the research agreement with Indivior has been extended until June 30, 2024 and Indivior committed additional research funding of CHF 2.7 million including CHF 1.1 million expected to be paid to the Group and CHF 1.6 million paid directly by Indivior to third party suppliers that are supporting the funded research program. On August 27, 2024, Indivior selected a compound for future development in substance use disorder and undertakes all future development of their selected compound. Under the terms of the agreement, the Group has also exercised its right to select a compound to advance its own independent GABAB PAM program for the treatment of chronic cough.

 

For the three-month and nine-month periods ended September 30, 2024, the Group recognized CHF 0.1 million and CHF 0.4 million as revenue in continuing operations (for the three-month and nine-month periods ended September 30, 2023, CHF 0.3 million and CHF 1.5 million respectively) and recorded CHF 0.1 million in contract asset and trade receivables as of September 30, 2024 and December 31, 2023.

 

Janssen Pharmaceuticals Inc. (formerly Ortho-McNeil-Janssen Pharmaceuticals Inc)

 

On December 31, 2004, the Group entered into a research collaboration and license agreement with Janssen Pharmaceuticals Inc. (JPI). In accordance with this agreement, JPI has acquired an exclusive worldwide license to develop mGlu2 PAM compounds for the treatment of human health. The Group is eligible to receive up to EUR 109 million in success-based development and regulatory milestone, and low double-digit royalties on net sales. The Group considers these various milestones to be variable considerations as they are contingent upon achieving uncertain, future development stages and net sales. For this reason, the Group considers the achievement of the various milestones as binary events that will be recognized as revenue occurs.

 

In April 2024, Janssen completed a Phase 2a proof of concept clinical trial of ADX71149 in epilepsy patients that did not achieve statistical significance for the primary endpoint of time for patients to reach baseline seizure count when ADX71149 was added to standard of care. On July 22, 2024, we reported that Janssen had terminated development of ADX71149 and the Group was now working with its partner to evaluate the programs’ future development.

 

No amounts have been recognized under this agreement for the nine-month periods ended September 30, 2024 and 2023.

 

17. Other income

 

Under grant agreements with Eurostars/Innosuisse the Group was required to complete specific research activities within a defined period of time. The Group’s funding was fixed and received based on the satisfactory completion of the agreed research activities and incurring the related costs.

 

In September 2023, the Group was awarded a grant of CHF 0.5 million by Eurostars/Innosuisse to support the mGlu2 NAM program of which CHF 0.3 million were received in December 2023. The Group recognized CHF 38,401 from January 1, 2024 to April 2, 2024, the date when the program was transferred to Neurosterix Pharma Sàrl and recorded as discontinued operations (note 21). The remaining funds and deferred income of CHF 0.3 million recorded as assets and liabilities held for sale as of April 2, 2024, has been transferred to Neurosterix Pharma Sàrl.

 

The Group additionally recognized other income from IT consultancy agreements.

 

18

 

 

Addex Therapeutics │ Unaudited Interim Condensed Consolidated Financial Statements │Notes

 

18. Operating costs

 

   For the three months
ended September 30,		   For the nine months
ended September 30,		 
   2024   2023*   2024   2023* 
Staff costs (note 19)   67,584    54,885    204,225    175,308 
Depreciation (notes 8/9)   53,575    2,938    168,895    8,814 
External research and development costs   77,847    421,153    441,418    850,220 
Patent maintenance and registration costs   91,856    62,601    215,730    175,999 
Professional fees   212,911    261,704    1,040,954    924,159 
D&O Insurance   56,753    157,399    169,431    472,311 
Other operating costs   120,020    117,776    477,488    369,507 
Total operating costs   680,546    1,078,456    2,718,141    2,976,318 

 

The evolution of the total operating costs is mainly driven by external research and development costs and professional fees.

 

During the nine-month period ended September 30, 2024, total operating costs recognized as continuing operations decreased by CHF 0.3 million compared to the same period ended September 30, 2023, primarily due to decreased external research and development cost of CHF 0.4 million and lower D&O insurance of CHF 0.3 million, partially offset by increased depreciation of CHF 0.2 million related to the intangible asset recorded at the fair value of the service agreement provided at zero cost (note 10) and higher professional fees of CHF 0.1 million.

 

During the three-month period ended September 30, 2024 total operating costs recognized as continuing operations decreased by CHF 0.4 million compared to the same period ended September 30, 2023, primarily due to decreased external research and development cost of CHF 0.3 million and lower D&O insurance of CHF 0.1 million.

 

During the nine-month periods ended September 30, 2023 and 2024, the total operating costs recognized as discontinued operations amounted to CHF 6.1 million and CHF 2.0 million respectively and primarily related to staff costs and external research and development costs (note 21).

 

19. Staff costs

 

   For the three months
ended September 30,		   For the nine months
ended September 30,		 
   2024   2023*   2024   2023* 
Wages and salaries   54,956    38,749    163,279    128,770 
Social charges and insurances   5,425    4,893    17,388    15,083 
Value of share-based services   3,813    7,785    14,460    22,481 
Retirement benefit (note 15)   3,390    3,458    9,098    8,974 
Total staff costs   67,584    54,885    204,225    175,308 

 

During the nine-month period ended September 30, 2024, staff costs recognized as continuing operating costs remained stable at CHF 0.2 million compared to the same period ended September 30, 2023.

 

During the nine-month periods ended September 30, 2023 and 2024, staff costs recognized as discontinued operations amounted to CHF 3.9 million and CHF 1.4 million, respectively (note 21).

 

20. Finance result, net

 

   For the three months
ended September 30,		   For the nine months
ended September 30,		 
   2024   2023*   2024   2023* 
Interest income   102    13,658    9,180    50,833 
Interest cost   (80)   -    (663)   (93)
Interest expense on leases   (506)   (538)   (1,398)   (1,720)
Foreign exchange gain /(loss), net   (29,956)   25,382    (11,341)   (138,085)
Finance result, net   (30,440)   38,502    (4,222)   (89,065)

 

19

 

 

Addex Therapeutics │ Unaudited Interim Condensed Consolidated Financial Statements │Notes

 

21. Discontinued operations

 

On February 8, 2024, the Group signed a non-binding term sheet with Perceptive Advisors related to the divestment of part of its business. On April 2, 2024, the sale became effective. The allosteric modulator drug discovery technology platform and a portfolio of preclinical programs have been divested to a new Swiss company, Neurosterix Pharma Sàrl that has received committed funding of USD 63 million from a syndicate of investors led by Perceptive Advisors (Perceptive Xontogeny Venture Fund II L.P, Perceptive Life Sciences Master Fund Ltd and Acorn Bioventures 2, L.P) (the “Neurosterix Transaction” or “Transaction”). As part of the Transaction, the Group received gross proceeds of CHF 5.0 million in cash and an equity interest representing 20% of Neurosterix US Holdings LLC (note 1). The Group retained its partnerships with Janssen Pharmaceuticals, Inc. and Indivior PLC, as well as unpartnered clinical stage assets including dipraglurant for Parkinson’s disease and post-stroke/TBI recovery and its preclinical GABAB PAM program for chronic cough. The Transaction includes the transfer of the associated R&D staff and infrastructure. As part of the Transaction, the Group and Neurosterix Pharma Sàrl entered into a service agreement which provides the Group with access to certain staff and infrastructure at zero cost to ensure the operation of the Group retained business.

 

As the allosteric modulator drug discovery technology platform and a portfolio of preclinical programs have been sold on April 2, 2024, such activities have been identified as discontinued operations for the nine-month period ended September 30, 2023 and for the period beginning on January 1, 2024 and terminating on April 1, 2024.

 

Financial performance of discontinued operations:

 

   For the three months
ended September 30,		   For the nine months
ended September 30,		 
   2024   2023   2024   2023 
Other income   -    -    38,401    - 
Research and development   -    (1,303,587)   (1,337,936)   (4,306,123)
General and administration   -    (599,782)   (673,259)   (1,779,689)
Total operating costs   -    (1,903,369)   (2,011,195)   (6,085,812)
Operating loss   -    (1,903,369)   (1,972,794)   (6,085,812)
Finance expense   -    (2,965)   (5,672)   (11,438)
Net loss before tax   -    (1,906,334)   (1,978,466)   (6,097,250)
Income tax expense   -    -    -    - 
Net loss from discontinued operations   -    (1,906,334)   (1,978,466)   (6,097,250)
Net gain / (loss) of the sale of activities after income tax   (2,400)   -    13,959,500    - 
Total net gain / (loss) from discontinued operations   (2,400)   (1,906,334)   11,981,034    (6,097,250)

 

Operating costs of discontinued operations:

 

   For the three months
ended September 30,		   For the nine months
ended September 30,		 
   2024   2023   2024   2023 
Staff costs   -    1,267,643    1,422,182    3,902,608 
Depreciation   -    72,442    67,422    217,752 
External research and development cost   -    412,321    333,278    1,443,897 
Laboratory consumables   -    61,220    17,735    239,993 
Patent maintenance and registration costs   -    3,079    62,563    8,372 
Professional fees   -    -    38,271    - 
Short-term leases   -    8,376    8,329    26,871 
Other operating costs   -    78,288    61,415    246,319 
Total discontinued operating costs   -    1,903,369    2,011,195    6,085,812 

 

Discontinued operating costs are primarily driven by staff and external research and development costs.

 

20

 

 

Addex Therapeutics │ Unaudited Interim Condensed Consolidated Financial Statements │Notes

 

Cash flows of discontinued operations:

 

   For the nine months
ended September 30,		 
   2024   2023 
Net profit / (loss) from discontinued operations   11,981,034    (6,097,250)
Adjustments for:          
    Net gain on Neurosterix Transaction   (13,959,500)   - 
    Value of share-based services   327,681    1,186,396 
    Post-employment benefits   (27,338)   (44,056)
    Depreciation   67,422    217,752 
    Net gain related to lease modifications   -    (318)
    Finance cost net   5,672    11,438 
Decrease / (increase) in trade and other receivables   (394,534)   124,832 
Increase in prepayments   (151,695)   (32,337)
Increase in other current assets   (5,000)   - 
Decrease in payables and accruals   (795,224)   (502,338)
Decrease in deferred income   (38,401)   - 
Net cash flow used in operating activities   (2,989,883)   (5,135,881)
           
Net cash flow from / (used in) investing activities          
Cash received from Neurosterix Transaction   5,119,754    - 
Legal fees paid for Neurosterix Transaction   (457,365)   - 
Purchase of property, plant and equipment   -    (5,637)
Net cash from / (used) in investing activities   4,662,389    (5,637)
           
Cash flows used in financing activities          
Principal element of lease payment   (63,770)   (204,172)
Interest paid   (5,672)   (11,438)
Net cash used in financing activities   (69,442)   (215,610)
           
Net cash from / (used in) discontinued activities   1,603,064    (5,357,128)

 

Net cash flow from discontinued activities amounts to CHF 1.6 million for the nine-month period ended September 30, 2024 and includes a gross proceeds of CHF 5.0 million from the sale of activities partially offset by operating costs of CHF 3.0 million incurred by activities transferred to Neurosterix Pharma Sàrl on April 2, 2024 and legal fees of CHF 0.5 million paid for Neurosterix Transaction.

 

Details of the net gain of the sale of activities:

 

   For the three
months ended
September 30, 2024		   For the nine
months ended
September 30, 2024		 
Consideration received          
Cash in from Neurosterix Pharma Sàrl sale   -    5,000,000 
Fair value of Neurosterix US Holdings LLC’s participation   -    9,428,400 
Net gain on Neurosterix Pharma Sàrl derecognition (IFRS10)   -    539,250 
Retirement benefit obligation of employees leaving the Group (IAS 19)   -    433,791 
Fair value of service agreement   -    182,348 
Net debt liabilities related to Neurosterix Pharma Sàrl (IFRS 16)   -    11,144 
Total disposal consideration   -    15,594,933 
Investment in Neurosterix Pharma Sàrl   -    (20,000)
Legal fees paid for Neurosterix Transaction   (2,400)   (457,364)
Accelerating vesting ESOP/DSPPP   -    (1,158,069)
Total costs related to activities sold   (2,400)   (1,635,433)
Net gain / (loss) on sale before income tax   (2,400)   13,959,500 
Income tax expense on gain   -    - 
Net gain / (loss) on sale after income tax   (2,400)   13,959,500 

 

As of September 30, 2024, the net fair value of the sales of activities amounted to CHF 14.0 million including CHF 5.0 million in cash and CHF 9.4 million for the equity interest of 20% in Neurosterix US Holdings LLC.

 

21

 

 

Addex Therapeutics │ Unaudited Interim Condensed Consolidated Financial Statements │Notes

 

22. Interests in associates

 

On April 2, 2024, the Group received an equity interest of 20% in Neurosterix US Holdings LLC parent company of Neurosterix Pharma Sàrl. The carrying amount of equity-accounted investments has changed as follow during the three-month and nine-month periods ended on September 30, 2024:

 

   For the three months
ended September 30,
2024		   For the nine months
ended September 30,
2024		 
Beginning of the period   8,897,651    - 
Fair value of Neurosterix US Holdings LLC equity interest on April 2, 2024   -    9,428,400 
Share of net loss for the period of Neurosterix’s Group   (874,933)   (1,405,682)
End of the period   8,022,718    8,022,718 

 

The initial recognition of the fair value of the 20% equity interests in Neurosterix US holdings LLC received by the Group is based on a financial valuation of the Neurosterix’s Group.

 

23. Profit or loss per share

 

Basic profit or loss per share is calculated by dividing the profit or loss attributable to equity holders of the Company by the weighted average number of outstanding shares.

 

Diluted profit per share is calculated by dividing the profit attributable to equity holders of the Company by the weighted average number of outstanding shares adjusted by outstanding options and warrants. Diluted loss per share is calculated excluding our options and warrants as they would be antidilutive and our treasury shares.

 

   For the three months
ended September 30,		   For the nine months
ended September 30,		 
   2024   2023   2024   2023 
                 
Net loss from continuing operations   (1,527,572)   (710,736)   (3,719,511)   (1,602,141)
Net profit / (loss) from discontinued operations   (2,400)   (1,906,334)   11,981,034    (6,097,250)
Net profit / (loss) attributable to equity holders of the company   (1,529,972)   (2,617,070)   8,261,523    (7,699,391)
                     
Basic profit / (loss) per share   (0.02)   (0.03)   0.08    (0.11)
From continuing operations   (0.02)   (0.01)   (0.04)   (0.02)
From discontinued operations   -    (0.02)   0.12    (0.09)
                     
Diluted profit / (loss) per share   (0.02)   (0.03)   0.05    (0.11)
From continuing operations   (0.02)   (0.01)   (0.04)   (0.02)
From discontinued operations   -    (0.02)   0.07    (0.09)

 

   For the three months
ended September 30,		   For the nine months
ended September 30,		 
   2024   2023   2024   2023 
                 
Weighted average number of outstanding shares (1)   98,301,596    77,278,532    98,038,838    70,299,213 
Weighted average number of outstanding shares including share options and warrants (2)   167,984,122    170,537,585    167,535,037    141,585,269 

 

(1)For the calculation of basic profit and loss per share and diluted loss per share
(2)For the calculation of the diluted profit per share

 

22

 

 

Addex Therapeutics │ Unaudited Interim Condensed Consolidated Financial Statements │Notes

 

24. Related party transactions

 

Related parties include members of the Board of Directors and the Executive Management of the Group. The following transactions were carried out with related parties:

 

Key management compensation

 

  For the three months
ended September 30,		   For the nine months
ended September 30,		 
   2024   2023   2024   2023 
   Continuing operations   Continuing operations 
Salaries, other short-term employee benefits and post-employment benefits   81,853    39,885    237,615    119,890 
Consulting fees   -    3,889    -    13,614 
Share-based compensation   37,579    64,940    136,346    186,738 
Total   119,432    108,714    373,961    320,242 

 

The total compensation costs to key management related to continuing operations remained stable during the nine-month periods ended September 30, 2023 and 2024.

 

Key management compensation

 

  For the three months
ended September 30,		   For the nine months
ended September 30,		 
   2024   2023   2024   2023 
   Discontinued operations   Discontinued operations 
Salaries, other short-term employee and post-employment benefits   -    316,620    664,525    1,164,120 
Share-based compensation   -    351,950    1,260,638    1,013,692 
Total   -    668,570    1,925,163    2,177,812 

 

The Group has a net payable to the Board of Directors and Executive Management of CHF 0.1 million as of September 30, 2024 (December 31, 2023: CHF 0.1 million). Share-based compensation relates to the fair value of equity incentive units recognized through our statement of profit or loss following their vesting plan.

 

25. Events after the balance sheet date

 

There were no material events between the balance sheet date and the date on which these financial statements were approved by the board of directors that would require adjustment to the financial statements or disclosure under this heading.

 

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