<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0708</schemaVersion>

    <submissionType>D/A</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001573901</cik>
        <entityName>Origin Life Sciences, Inc.</entityName>
        <issuerAddress>
            <street1>2 RESEARCH WAY</street1>
            <street2>THIRD FLOOR</street2>
            <city>PRINCETON</city>
            <stateOrCountry>NJ</stateOrCountry>
            <stateOrCountryDescription>NEW JERSEY</stateOrCountryDescription>
            <zipCode>08540</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>(609)250-6000</issuerPhoneNumber>
        <jurisdictionOfInc>DELAWARE</jurisdictionOfInc>
        <issuerPreviousNameList>
            <previousName>Plasma Jet Technologies, Inc.</previousName>
        </issuerPreviousNameList>
        <edgarPreviousNameList>
            <previousName>Origin, Inc.</previousName>
            <previousName>Advanced Plasma Therapies, Inc.</previousName>
        </edgarPreviousNameList>
        <entityType>Corporation</entityType>
        <yearOfInc>
            <overFiveYears>true</overFiveYears>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Michael</firstName>
                <middleName>David</middleName>
                <lastName>Preston</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Origin Life Sciences, Inc.</street1>
                <street2>2 Research Way, Third Floor</street2>
                <city>Princeton</city>
                <stateOrCountry>NJ</stateOrCountry>
                <stateOrCountryDescription>NEW JERSEY</stateOrCountryDescription>
                <zipCode>08540</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification>Chief Executive Officer</relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>David</firstName>
                <lastName>Dantzker</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Origin Life Sciences, Inc.</street1>
                <street2>2 Research Way, Third Floor</street2>
                <city>Princeton</city>
                <stateOrCountry>NJ</stateOrCountry>
                <stateOrCountryDescription>NEW JERSEY</stateOrCountryDescription>
                <zipCode>08540</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification>Chief Medical Officer</relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>John</firstName>
                <lastName>Fernandes</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Origin Life Sciences, Inc.</street1>
                <street2>2 Research Way, Third Floor</street2>
                <city>Princeton</city>
                <stateOrCountry>NJ</stateOrCountry>
                <stateOrCountryDescription>NEW JERSEY</stateOrCountryDescription>
                <zipCode>08540</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification>Chief Financial Officer</relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Anthony</firstName>
                <lastName>Brampton</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Origin Life Sciences, Inc.</street1>
                <street2>2 Research Way, Third Floor</street2>
                <city>Princeton</city>
                <stateOrCountry>NJ</stateOrCountry>
                <stateOrCountryDescription>NEW JERSEY</stateOrCountryDescription>
                <zipCode>08540</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Victor</firstName>
                <lastName>Micati</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Origin Life Sciences, Inc.</street1>
                <street2>2 Research Way, Third Floor</street2>
                <city>Princeton</city>
                <stateOrCountry>NJ</stateOrCountry>
                <stateOrCountryDescription>NEW JERSEY</stateOrCountryDescription>
                <zipCode>08540</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Jerome</firstName>
                <middleName>Boda</middleName>
                <lastName>Korten</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>c/o Origin Life Sciences, Inc.</street1>
                <street2>2 Research Way, Third Floor</street2>
                <city>Princeton</city>
                <stateOrCountry>NJ</stateOrCountry>
                <stateOrCountryDescription>NEW JERSEY</stateOrCountryDescription>
                <zipCode>08540</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Biotechnology</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>Decline to Disclose</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06b</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>true</isAmendment>
                <previousAccessionNumber>0001213900-23-045117</previousAccessionNumber>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2023-05-30</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>5000</minimumInvestmentAccepted>
        <salesCompensationList>
            <recipient>
                <recipientName>Boustead Securities, LLC</recipientName>
                <recipientCRDNumber>141391</recipientCRDNumber>
                <associatedBDName>None</associatedBDName>
                <associatedBDCRDNumber>None</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>6 VENTURE</street1>
                    <street2>SUITE 395</street2>
                    <city>IRVINE</city>
                    <stateOrCountry>CA</stateOrCountry>
                    <stateOrCountryDescription>CALIFORNIA</stateOrCountryDescription>
                    <zipCode>92618</zipCode>
                </recipientAddress>
                <statesOfSolicitationList>
                    <state>AL</state>
                    <description>ALABAMA</description>
                    <state>FL</state>
                    <description>FLORIDA</description>
                    <state>NY</state>
                    <description>NEW YORK</description>
                </statesOfSolicitationList>
                <foreignSolicitation>false</foreignSolicitation>
            </recipient>
        </salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>850000</totalOfferingAmount>
            <totalAmountSold>659600</totalAmountSold>
            <totalRemaining>190400</totalRemaining>
            <clarificationOfResponse>Corporation and its stockholders are entering into a private placement offering of: (i) up to 425,000 shares of the Corporation's common stock, par value $0.01 per share, at a price per share of $2.00, for gross proceeds of up to $850,000.</clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>6</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>46172</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse></clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
            <clarificationOfResponse>While no offering proceeds are set aside for payments to the named officers or directors, it is possible that some proceeds to be used as working capital will be used indirectly for paying salaries to employees including executive officers.</clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>Origin Life Sciences, Inc.</issuerName>
                <signatureName>/s/ Michael D. Preston</signatureName>
                <nameOfSigner>Michael D. Preston</nameOfSigner>
                <signatureTitle>Chief Executive Officer and Chairman</signatureTitle>
                <signatureDate>2023-06-22</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
