<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0206</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2012-10-22</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001083446</issuerCik>
        <issuerName>Apollo Medical Holdings, Inc.</issuerName>
        <issuerTradingSymbol>AMEH</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001572821</rptOwnerCik>
            <rptOwnerName>Creem Mitchell</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>700 NORTH BRAND BLVD.</rptOwnerStreet1>
            <rptOwnerStreet2>SUITE 450</rptOwnerStreet2>
            <rptOwnerCity>GLENDALE</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>91203</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>500000</value>
                    <footnoteId id="F1"/>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">These shares were granted in connection with Mr. Creem's appointment as director on October 22, 2012, pursuant to a director agreement dated effective as of October 15, 2012. These shares represent restricted stock units that will be settled in common stock upon vesting. Pursuant to an agreement with the issuer, the shares of common stock will vest in 36 equal monthly installments. As of the date this report is being filed, 97,222 shares have vested.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Mitchell Creem</signatureName>
        <signatureDate>2013-04-10</signatureDate>
    </ownerSignature>
</ownershipDocument>
