X0306 4 2020-01-21 0 0001322505 ALBIREO PHARMA, INC. ALBO 0001572002 Horn Patrick Taylor C/O ALBIREO PHARMA, INC. 10 POST OFFICE SQUARE, SUITE 1000 BOSTON MA 02109 0 1 0 0 Chief Medical Officer Common Stock 2020-01-22 4 S 0 443 24.29 D 4557 D Stock Option (right to buy) 24.67 2020-01-21 4 A 0 31500 0.00 A 2030-01-20 Common Stock 31500 31500 D Shares sold pursuant to a Rule 10b5-1 arrangement to satisfy tax obligations arising out of the vesting of previously granted restricted stock units. Represents 807 shares of common stock and 3,750 restricted stock units. This option vests as to 25% of the shares on January 21, 2021, with the remainder vesting in equal installments every three months thereafter beginning on April 21, 2021 and ending on January 21, 2024, provided that the vesting of the option may be accelerated, in whole or in part, based on the achievement of certain pre-established company performance criteria, but in no event prior to January 21, 2021. /s/ Jason Duncan, Attorney-in-fact 2020-01-23