X0306 4 2018-02-08 0 0001638287 Gemphire Therapeutics Inc. GEMP 0001571997 Gullans Steven R. Ph.D. 17199 N. LAUREL PARK DRIVE SUITE 401 LIVONIA MI 48152 1 1 0 0 Interim President & CEO Common Stock 2018-02-08 4 P 0 71429 7 A 930252 I Held by Excel Venture Fund II, L.P. The shares were purchased in a confidentially marketed public offering pursuant to an Underwriting Agreement. The offering closed on February 12, 2018. The reporting person, as the Manager of Excel Venture Fund II, L.P., beneficially owns the reported securities indirectly, but disclaims beneficial ownership of the securities except to the extent of his pecuniary interest therein. /s/ Stephanie Swan, by Power of Attorney 2018-02-12