X0306 4 2016-01-12 0 0001571498 Epizyme, Inc. EPZM 0001110780 GOLDFISCHER CARL 11 BELVEDERE AVE BELVEDERE CA 94920 1 0 0 0 Common Stock, par value $0.0001 per share 2016-01-12 4 P 0 545166 9.00 A 3370562 I See Footnote Common Stock, par value $0.0001 per share 2016-01-12 4 P 0 10389 9.00 A 3380951 I See Footnote Reports the purchase of shares in the underwritten public offering of common stock of Epizyme, Inc. Represents shares held by Bay City Capital Fund V, L.P. ("Fund V"); and indirect interests of Bay City Capital ("BCC"), the manager of Bay City Capital Management V LLC ("Management V"), and Management V, the general partner of Fund V. Dr. Goldfischer is Managing Director of BCC. Dr. Goldfischer, BCC and Management V each disclaims beneficial ownership in such shares, except to the extent of their pecuniary interest therein. Represents shares held by Bay City Capital Fund V Co-Investment Fund, L.P. ("Co-Investment V"); and indirect interests of BCC, the manager of Management V, and Management V, the general partner of Fund V. Dr. Goldfischer is Managing Director of BCC. Dr. Goldfischer, BCC and Management V each disclaims beneficial ownership in such shares, except to the extent of their pecuniary interest therein. /s/ Carl Goldfischer 2016-01-12