0001193125-20-131670.txt : 20200504 0001193125-20-131670.hdr.sgml : 20200504 20200504064236 ACCESSION NUMBER: 0001193125-20-131670 CONFORMED SUBMISSION TYPE: 8-K PUBLIC DOCUMENT COUNT: 13 CONFORMED PERIOD OF REPORT: 20200504 ITEM INFORMATION: Results of Operations and Financial Condition ITEM INFORMATION: Financial Statements and Exhibits FILED AS OF DATE: 20200504 DATE AS OF CHANGE: 20200504 FILER: COMPANY DATA: COMPANY CONFORMED NAME: Epizyme, Inc. CENTRAL INDEX KEY: 0001571498 STANDARD INDUSTRIAL CLASSIFICATION: PHARMACEUTICAL PREPARATIONS [2834] IRS NUMBER: 261349956 STATE OF INCORPORATION: DE FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: 8-K SEC ACT: 1934 Act SEC FILE NUMBER: 001-35945 FILM NUMBER: 20842697 BUSINESS ADDRESS: STREET 1: 400 TECHNOLOGY SQUARE STREET 2: 4TH FLOOR CITY: CAMBRIDGE STATE: MA ZIP: 02139 BUSINESS PHONE: 617-229-5872 MAIL ADDRESS: STREET 1: 400 TECHNOLOGY SQUARE STREET 2: 4TH FLOOR CITY: CAMBRIDGE STATE: MA ZIP: 02139 8-K 1 d919800d8k.htm 8-K 8-K
false 0001571498 0001571498 2020-05-04 2020-05-04

 

 

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, DC 20549

 

FORM 8-K

 

CURRENT REPORT

Pursuant to Section 13 or 15(d)

of the Securities Exchange Act of 1934

Date of report (Date of earliest event reported): May 4, 2020

 

EPIZYME, INC.

(Exact Name of Registrant as Specified in Charter)

 

Delaware

  

001-35945

  

26-1349956

(State or Other Jurisdiction
of Incorporation)

  

(Commission
File Number)

  

(IRS Employer
Identification No.)

400 Technology Square,

Cambridge, Massachusetts

  

02139

(Address of Principal Executive Offices)

  

(Zip Code)

Registrant’s telephone number, including area code: (617) 229-5872

(Former Name or Former Address, if Changed Since Last Report)

 

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:

☐ Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)

☐ Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)

☐ Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))

☐ Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

Securities registered pursuant to Section 12(b) of the Act:

Title of each class

  

Trading

symbol

  

Name of each exchange

on which registered

Common stock, $0.0001 par value

  

EPZM

  

Nasdaq Global Select Market

Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§240.12b-2 of this chapter).

Emerging growth company  ☐

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act.  ☐

 

 

Item 2.02 Results of Operations and Financial Condition

On May 4, 2020, Epizyme, Inc., a Delaware corporation (the “Company”) announced its financial results for the quarter ended March 31, 2020. The full text of the press release issued in connection with the announcement is furnished as Exhibit 99.1 to this Current Report on Form 8-K and is incorporated herein by reference.

The information provided under Item 2.02 of this Form 8-K (including Exhibit 99.1) shall not be deemed “filed” for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”) or otherwise subject to the liabilities of that section, nor shall it be deemed incorporated by reference in any filing under the Securities Act of 1933, as amended, or the Exchange Act, except as expressly set forth by specific reference in such a filing.

Item 9.01 Financial Statements and Exhibits

(d)    Exhibits

99.1 Press release issued by the Company on May 4, 2020*

104 Cover Page Interactive Date File (embedded within Inline XBRL document)

* The exhibit shall be deemed to be furnished, and not filed.

SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

 

 

EPIZYME, INC.

             

Date: May 4, 2020

 

 

By:

 

/s/ Robert B. Bazemore

 

 

 

Robert B. Bazemore

 

 

 

President and Chief Executive Officer

EX-99.1 2 d919800dex991.htm EX-99.1 EX-99.1

Exhibit 99.1

Epizyme Reports Business Progress and First Quarter 2020 Financial Results

TAZVERIK™ Successfully Launched for First Approved Indication; PDUFA Date of June 18,

2020 for sNDA for Follicular Lymphoma Indication

Business Continuity Plans in Place in Response to COVID-19

Conference Call to be Held Today, May 4 at 9:00 a.m. ET

CAMBRIDGE, Mass., May 4, 2020 – Epizyme, (Nasdaq: EPZM), a fully integrated, commercial-stage biopharmaceutical company developing novel epigenetic therapies, today provided business and pipeline updates and reported first quarter 2020 financial results.

“The first quarter of 2020 was significant for Epizyme, marked by the FDA approval of TAZVERIK™ in eligible patients with epithelioid sarcoma and our transition to a commercial-stage company,” said Robert Bazemore, president and chief executive officer of Epizyme. “Despite the global challenges as a result of the COVID-19 pandemic, and the continued uncertainties in the recovery process, we know that patients with cancer still need better treatments, and we remain committed to advancing innovative medicines on their behalf. In addition to continuing our commercialization of TAZVERIK for epithelioid sarcoma, a critical activity for our organization, we are preparing to launch in follicular lymphoma, should TAZVERIK be approved for that indication. We believe strongly in TAZVERIK’s potential to make a meaningful impact in the lives of patients.”

COVID-19 Response

In response to the ongoing COVID-19 pandemic, Epizyme has activated business continuity plans to allow for the continued advancement of TAZVERIK commercialization, tazemetostat clinical development expansion and the company’s early pipeline, which are designed to minimize disruptions and protect the safety of its employees. Epizyme continues to assess the situation and any potential impact it may have on its operations, financial guidance and plans, and will provide updates accordingly. Measures implemented to date that address challenges resulting from the global pandemic include:

 

  •  

Employee Safety and Remote Operations: A remote operating model for in-house and field-based employees was implemented in early March, with the exception of a small number of employees to continue critical lab and information technology operations.

 

  •  

Patient Access to TAZVERIK: Epizyme is leveraging a specialty pharmacy and specialty distributors to support seamless patient access, and currently expects to be able to provide an uninterrupted supply of TAZVERIK for commercial use and the company’s ongoing clinical trials.

 

  •  

U.S. Commercialization: Epizyme is leveraging virtual personal and non-personal approaches to engage and reach customers.

  •  

Supporting Ongoing Clinical Trials: Epizyme is working with clinical trial sites and clinical research organizations to implement virtual capabilities for site initiations and trial monitoring, as well as alternative methods to assist with patient participation.

Recent Progress

 

  •  

TAZVERIK Commercially Available in U.S. for Epithelioid Sarcoma (ES): Epizyme successfully made TAZVERIK commercially available in the U.S. on February 1, 2020, following its accelerated approval on January 23, 2020, for the treatment of adults and pediatric patients aged 16 years and older with metastatic or locally advanced ES not eligible for complete resection. Within one week from approval, the first prescriptions were filled, and the company saw continued traction in the first quarter, with physicians incorporating TAZVERIK into their treatment practices.

 

  •  

Follicular Lymphoma (FL) U.S. Commercial Launch Readiness Nearly Complete: The U.S. Food and Drug Administration (FDA) granted Priority Review to Epizyme’s supplemental New Drug Application (sNDA) filing with a PDUFA target action date of June 18, 2020 for the accelerated approval of TAZVERIK for a proposed indication of patients with relapsed or refractory FL who have received at least two prior lines of systemic therapy. To support a potential FDA approval, the company has concluded the hiring and training of its salesforce and is completing its FL launch readiness activities, which will utilize both direct and virtual approaches to physician education.

 

  •  

Company-sponsored Trials in ES, FL and Prostate Cancer Underway: Epizyme expects to complete the ongoing safety run-in portions and begin the efficacy expansion portions of the following clinical trials in 2020:

 

  •  

Global, randomized, controlled confirmatory Phase 1b/3 trial assessing the combination of TAZVERIK plus doxorubicin compared with doxorubicin plus placebo as a front-line treatment for ES patients;

 

  •  

Global randomized, controlled confirmatory Phase 1b/3 trial assessing TAZVERIK in combination with “R2” (Revlimid® plus rituximab) compared with R2 plus placebo in the second-line FL treatment setting; and

 

  •  

Global randomized, controlled Phase 1b/2 clinical trial in chemo-naïve patients with metastatic castration-resistant prostate cancer, assessing tazemetostat with enzalutamide or with abiraterone, standard treatments for this patient population.

 

  •  

Additional Investigator-Sponsored Trials Advancing: Epizyme is supporting a number of investigator-sponsored studies assessing tazemetostat in multiple combinations, including in front-line and relapsed/refractory treatment settings for FL.

Financial Guidance

Based on its current operating plans, Epizyme continues to believe that its existing cash, cash equivalents and marketable securities will fund the company’s operations into at least 2022. The company expects its non-GAAP adjusted operating expenses for 2020 will be between $235 and $255 million, which excludes any milestone payments paid by the company and non-cash items, such as stock-based compensation and amortization or depreciation of intangibles.

First Quarter 2020 Financial Results

 

  •  

Cash Position: Cash, cash equivalents and marketable securities were $376.5 million as of March 31, 2020, as compared to $381.1 million as of December 31, 2019.

 

  •  

Revenue: Total revenue for the first quarter of 2020 was $1.4 million, comprised of $1.3 million in net sales of TAZVERIK in the U.S. from the first two months of commercialization following its launch in January 2020 and $0.1 million in collaboration revenue, compared to $4.3 million in collaboration revenue for the fourth quarter of 2019, which was primarily due to revenue associated with services performed under the company’s multi-target research collaboration with Boehringer Ingelheim.

 

  •  

Operating Expenses: Total GAAP operating expenses were $52.7 million for first quarter of 2020, compared to $61.8 million for the fourth quarter of 2019. Total non-GAAP adjusted cash operating expenses, were $45.7 million for the first quarter of 2020, compared to $45.2 million for the fourth quarter of 2019.

 

  •  

R&D expenses: GAAP R&D expenses were $25.2 million for the first quarter of 2020, compared to $38.3 million for the fourth quarter of 2019, while non-GAAP adjusted R&D expenses were $22.9 million for the first quarter of 2020, compared to $25.8 million for the fourth quarter of 2019. The decrease was primarily due to one-time expenses related to the company’s Oncology Drug Advisory Committee (ODAC) meeting and FL NDA submission in the fourth quarter of 2020.

 

  •  

SG&A expenses: GAAP SG&A expenses were $ 26.9 million for the first quarter of 2020, compared to $23.5 million for the fourth quarter of 2019, while non-GAAP SG&A adjusted expenses were $22.5 million for the first quarter of 2020, compared to $19.4 million for the fourth quarter of 2019. The increase was primarily due to expenses related to the company’s buildout of its salesforce and infrastructure to support its commercial launch of TAZVERIK for the ES indication and expansion of its infrastructure to support a potential launch in FL.

 

  •  

Net Loss (GAAP): Net loss attributable to common stockholders was $50.9 million, or $0.51 per share, for the first quarter of 2020, compared to $56.4 million, or $0.59 per share, for the fourth quarter of 2019.

A reconciliation of non-GAAP financial measures directly comparable to GAAP financial measures is presented in the table attached to this press release.

Conference Call Information

Epizyme will host a conference call today, May 4, at 9:00 a.m. ET. To participate in the conference call, please dial (877) 844-6886 (domestic) or (970) 315-0315 (international) and refer to conference ID 1329067. A webcast will be available in the investor section of the company’s website at www.epizyme.com, and will be archived for 60 days following the call.

About Non-GAAP Financial Measures

In addition to financial information prepared in accordance with the U.S. generally accepted accounting principles (GAAP), this press release includes the following non-GAAP financial measures: total non-GAAP adjusted operating expenses on a historical and projected basis, non-GAAP R&D expenses on a historical basis and non-GAAP G&A expenses on a historical basis. Epizyme derives these non-GAAP financial measures by excluding certain expenses and other items from the respective GAAP financial measure, that is most directly comparable to each non-GAAP financial measure. Specifically, the non-GAAP financial measures exclude stock-based compensation expense, amortization or depreciation of intangibles and milestone payments related to TAZVERIK, which are payable under the company’s collaboration agreement with Eisai Pharmaceuticals. The company’s management believes that these non-GAAP financial measures are useful to both management and investors in analyzing its ongoing business and operating performance. Management does not intend the presentation of these non-GAAP financial measures to be considered in isolation or as a substitute for results prepared in accordance with GAAP, but as a complement to provide greater transparency. In addition, these non-GAAP financial measures may differ from similarly named measures used by other companies. A quantitative reconciliation of projected non-GAAP adjusted operating expenses to total operating expenses is not available without unreasonable effort primarily due to the company’s inability to predict with reasonable certainty the amount of future stock-based compensation expense.

About TAZVERIK

TAZVERIK™ (tazemetostat) is the first EZH2 inhibitor approved by the U.S. Food and Drug Administration (FDA). TAZVERIK™ is an enhancer of zeste homolog 2 (EZH2) methyltransferase inhibitor indicated for the treatment of adults and pediatric patients aged 16 years and older with metastatic or locally advanced epithelioid sarcoma who are not eligible for complete resection. TAZVERIK is generally well tolerated. The most common adverse reactions (³20%) were pain, fatigue, nausea, decreased appetite, vomiting and constipation. Serious adverse reactions occurred in 37% of patients receiving TAZVERIK. Serious adverse reactions in ³3% of patients who received TAZVERIK were hemorrhage, pleural effusion, skin infection, dyspnea, pain and respiratory distress.

This indication is approved under accelerated approval based on overall response rate and duration of response. Continued approval for this indication may be contingent upon verification and description of clinical benefit in a confirmatory trial(s). For more information, visit TAZVERIK.com.

About Epizyme, Inc.

Epizyme, Inc. is a fully integrated, commercial-stage biopharmaceutical company committed to its mission of rewriting treatment for cancer and other serious diseases through novel epigenetic medicines. In addition to an active research and discovery pipeline, Epizyme has one U.S. FDA approved product, TAZVERIK™ (tazemetostat), for the treatment of adults and pediatric patients aged 16 years and older with metastatic or locally advanced epithelioid sarcoma who are not eligible for complete resection. A supplemental New Drug Application is under Priority Review by the U.S. FDA for TAZVERIK for the treatment of patients with relapsed or refractory

follicular lymphoma who have received at least two prior lines of systemic therapy. The company is also exploring the treatment potential of tazemetostat in investigational clinical trials in other solid tumors and hematological malignancies, as a monotherapy and combination therapy in both relapsed and front-line disease settings. For more information, visit www.epizyme.com.

Cautionary Note on Forward-Looking Statements

Any statements in this press release about future expectations, plans and prospects for Epizyme, Inc. and other statements containing the words “anticipate,” “believe,” “estimate,” “expect,” “intend,” “may,” “plan,” “predict,” “project,” “target,” “potential,” “will,” “would,” “could,” “should,” “continue,” and similar expressions, constitute forward-looking statements within the meaning of The Private Securities Litigation Reform Act of 1995. Actual results may differ materially from those indicated by such forward-looking statements as a result of various important factors, including: whether tazemetostat will receive marketing approval for epithelioid sarcoma in other jurisdictions, full approval in the United States or approval in any other indication on a timely basis or at all, including approval of the company’s sNDA for FL; uncertainties related to the impact on the company’s business of the COVID-19 pandemic, including the commercial launch of TAZVERIK, ongoing and planned clinical trials and commercial and clinical supply of TAZVERIK; whether results from preclinical studies or earlier clinical studies will be predictive of the results of future trials, such as the ongoing confirmatory trials; whether results from clinical studies will warrant meetings with regulatory authorities, submissions for regulatory approval or review by governmental authorities under the accelerated approval process; expectations for regulatory approvals, including accelerated approval, to conduct trials or to market products; whether the company’s cash resources will be sufficient to fund the company’s foreseeable and unforeseeable operating expenses and capital expenditure requirements; other matters that could affect the availability or commercial success of tazemetostat or the company’s therapeutic candidates; and other factors discussed in the “Risk Factors” section of the company’s most recent Form 10-K filed with the SEC and in the company’s other filings from time to time with the SEC. In addition, the forward-looking statements included in this press release represent the company’s views as of the date hereof and should not be relied upon as representing the company’s views as of any date subsequent to the date hereof. The company anticipates that subsequent events and developments will cause the company’s views to change. However, while the company may elect to update these forward-looking statements at some point in the future, the company specifically disclaims any obligation to do so.

TAZVERIK™ is a trademark of Epizyme, Inc.

Contacts

Media:

Erin Graves, Epizyme, Inc.

media@epizyme.com

(617) 500-0615

Investors:

Alicia Davis, THRUST Strategic Communications

alicia@thrustsc.com

(910) 620-3302

EPIZYME, INC.

CONSOLIDATED BALANCE SHEET DATA (UNAUDITED)

(Amounts in thousands)

 

     March 31,      December 31,  
     2020      2019  
Consolidated Balance Sheet Data:      

Cash and cash equivalents

    $ 179,261      $ 139,482  

Marketable securities

      197,199        241,605  

Intangible assets, net

      24,702        —    

Total assets

      451,638        424,589  

Total current liabilities

      27,183        34,386  

Deferred revenue

      3,806        3,806  

Long-term debt, net of debt discount

      48,381        23,309  

Liability related to sale of future royalties

      13,087        12,793  

Total stockholders’ equity

    $ 340,318      $ 331,137  
  

 

 

     

 

 

  

EPIZYME, INC.

CONSOLIDATED STATEMENTS OF OPERATIONS (UNAUDITED)

(Amounts in thousands except per share data)

 

     Three Months Ended     Three Months Ended  
     March 31     December 31  
     2020     2019     2019  

Revenues

       

Product revenue, net

    $ 1,284     $ —       $ —    

Collaboration revenue

      70       7,891       4,294  
  

 

 

    

 

 

    

 

 

  

Total revenue

      1,354       7,891       4,294  
  

 

 

    

 

 

    

 

 

  

Operating expenses

       

Cost of product revenue

      614       —         —    

Research and development

      25,163       26,896       38,257  

Selling, general and administrative

      26,927       11,986       23,530  
  

 

 

    

 

 

    

 

 

  

Total operating expenses

      52,704       38,882       61,787  
  

 

 

    

 

 

    

 

 

  

Operating loss

      (51,350 )      (30,991 )      (57,493 ) 

Other income, net:

       

Interest income, net

      756       1,658       1,320  

Other (expense) income, net

      (48 )      (6 )      21  

Non-cash interest expense related to sale of future royalties

      (295 )      —         (192 ) 
  

 

 

    

 

 

    

 

 

  

Other income, net:

      413       1,652       1,149  
  

 

 

    

 

 

    

 

 

  

Loss before income taxes

      (50,937 )      (29,339 )      (56,344 ) 

Income tax provision

      —         —         (58 ) 
  

 

 

    

 

 

    

 

 

  

Net loss

    $ (50,937 )    $ (29,339 )    $ (56,402 ) 
  

 

 

    

 

 

    

 

 

  

Reconciliation of net loss to net loss attributable to common stockholders

       

Net loss

    $ (50,937 )    $ (29,339 )    $ (56,402 ) 

Accretion of convertible preferred stock

        (2,940 )   
  

 

 

    

 

 

    

 

 

  

Net loss attributable to common stockholders

    $ (50,937 )    $ (32,279 )    $ (56,402 ) 
  

 

 

    

 

 

    

 

 

  

Net loss per share attributable to common stockholders - basic and diluted

    $ (0.51 )    $ (0.39 )    $ (0.59 ) 

Weighted-average common shares outstanding used in net loss per share attributable to common stockholders - basic and diluted

      99,616       82,424       95,074  

EPIZYME, INC.

Reconciliation of Selected GAAP Measures to Non-GAAP Measures (UNAUDITED)

(Amounts in thousands)

 

     Three Months Ended     Three Months
Ended		  
     March 31     December 31  
Reconciliation of GAAP to Non-GAAP Cost of Product Revenue    2020     2019     2019  

GAAP Cost of Product Revenue

    $ 614     $ —       $ —    

Less: Depreciation and Amortization

      (298 )      —         —    
  

 

 

    

 

 

    

 

 

  

Non-GAAP Cost of Product Revenue

    $ 316     $ —       $ —    
  

 

 

    

 

 

    

 

 

  

Reconciliation of GAAP to Non-GAAP Research and Development

       

GAAP Research and Development

    $ 25,163     $ 26,896     $ 38,257  

Less: Stock-Based Compensation Expenses

      (2,162 )      (1,165 )      (2,294 ) 

Less: Depreciation and Amortization

      (138 )      (158 )      (146 ) 

Less: Eisai R&D Milestone Expense

      —         —         (10,000 ) 
  

 

 

    

 

 

    

 

 

  

Non-GAAP Research and Development

      22,863     $ 25,573     $ 25,817  
  

 

 

    

 

 

    

 

 

  

Reconciliation of GAAP to Non-GAAP Selling, General and Administrative:

 

    

GAAP Selling, General and Administrative

    $ 26,927     $ 11,986     $ 23,530  

Less: Stock-Based Compensation Expenses

      (4,348 )      (2,046 )      (4,106 ) 

Less: Depreciation and Amortization

      (93 )      (49 )      (68 ) 
  

 

 

    

 

 

    

 

 

  

Non-GAAP Selling, General and Administrative

    $ 22,486     $ 9,891     $ 19,356  
  

 

 

    

 

 

    

 

 

  

Reconciliation of GAAP to Non-GAAP Operating Expenses

       

GAAP Operating Expenses

    $ 52,704     $ 38,882     $ 61,787  

Less: Stock-Based Compensation Expenses

      (6,510 )      (3,211 )      (6,400 ) 

Less: Depreciation and Amortization

      (529 )      (207 )      (214 ) 

Less: Eisai R&D Milestone Expense

      —         —         (10,000 ) 
  

 

 

    

 

 

    

 

 

  

Non-GAAP Operating Expenses

    $ 45,665     $ 35,464     $ 45,173  
  

 

 

    

 

 

    

 

 

  
 EX-101.SCH 3 epzm-20200504.xsd XBRL TAXONOMY EXTENSION SCHEMA 100000 - Document - Document and Entity Information link:calculationLink link:presentationLink link:definitionLink EX-101.LAB 4 epzm-20200504_lab.xml XBRL TAXONOMY EXTENSION LABEL LINKBASE Cover [Abstract] Cover [Abstract] Amendment Flag Amendment Flag Entity Central Index Key Entity Central Index Key Document Type Document Type Document Period End Date Document Period End Date Entity Registrant Name Entity Registrant Name Entity Incorporation State Country Code Entity Incorporation State Country Code Entity File Number Entity File Number Entity Tax Identification Number Entity Tax Identification Number Entity Address, Address Line One Entity Address, Address Line One Entity Address, City or Town Entity Address, City or Town Entity Address, State or Province Entity Address, State or Province Entity Address, Postal Zip Code Entity Address, Postal Zip Code City Area Code City Area Code Local Phone Number Local Phone Number Written Communications Written Communications Soliciting Material Soliciting Material Pre Commencement Tender Offer Pre Commencement Tender Offer Pre Commencement Issuer Tender Offer Pre Commencement Issuer Tender Offer Security 12b Title Security 12b Title Trading Symbol Trading Symbol Security Exchange Name Security Exchange Name Entity Emerging Growth Company Entity Emerging Growth Company EX-101.PRE 5 epzm-20200504_pre.xml XBRL TAXONOMY EXTENSION PRESENTATION LINKBASE JSON 6 MetaLinks.json IDEA: XBRL DOCUMENT { "instance": { "d919800d8k.htm": { "axisCustom": 0, "axisStandard": 0, "contextCount": 1, "dts": { "inline": { "local": [ "d919800d8k.htm" ] }, "labelLink": { "local": [ "epzm-20200504_lab.xml" ], "remote": [ "https://xbrl.sec.gov/dei/2019/dei-doc-2019-01-31.xml" ] }, "presentationLink": { "local": [ "epzm-20200504_pre.xml" ] }, "referenceLink": { "remote": [ "https://xbrl.sec.gov/dei/2019/dei-ref-2019-01-31.xml" ] }, "schema": { "local": [ "epzm-20200504.xsd" ], "remote": [ "http://www.xbrl.org/2003/xbrl-instance-2003-12-31.xsd", "http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd", "http://www.xbrl.org/2003/xl-2003-12-31.xsd", "http://www.xbrl.org/2003/xlink-2003-12-31.xsd", "https://xbrl.sec.gov/dei/2019/dei-2019-01-31.xsd", "http://www.xbrl.org/2005/xbrldt-2005.xsd", "http://www.xbrl.org/dtr/type/nonNumeric-2009-12-16.xsd", "http://www.xbrl.org/dtr/type/numeric-2009-12-16.xsd", "http://xbrl.sec.gov/sic/2011/sic-2011-01-31.xsd", "https://xbrl.sec.gov/naics/2017/naics-2017-01-31.xsd", "http://www.xbrl.org/lrr/role/deprecated-2009-12-16.xsd", "http://www.xbrl.org/2006/ref-2006-02-27.xsd" ] } }, "elementCount": 23, "entityCount": 1, "hidden": { "http://xbrl.sec.gov/dei/2019-01-31": 2, "total": 2 }, "keyCustom": 0, "keyStandard": 95, "memberCustom": 0, "memberStandard": 0, "nsprefix": "epzm", "nsuri": "http://www.epizyme.com/20200504", "report": { "R1": { "firstAnchor": { "ancestors": [ "p", "div", "body", "html" ], "baseRef": "d919800d8k.htm", "contextRef": "duration_2020-05-04_to_2020-05-04", "decimals": null, "first": true, "lang": "en-US", "name": "dei:DocumentType", "reportCount": 1, "unique": true, "unitRef": null, "xsiNil": "false" }, "groupType": "document", "isDefault": "true", "longName": "100000 - Document - Document and Entity Information", "role": "http://www.epizyme.com//20200504/taxonomy/role/DocumentDocumentAndEntityInformation", "shortName": "Document and Entity Information", "subGroupType": "", "uniqueAnchor": { "ancestors": [ "p", "div", "body", "html" ], "baseRef": "d919800d8k.htm", "contextRef": "duration_2020-05-04_to_2020-05-04", "decimals": null, "first": true, "lang": "en-US", "name": "dei:DocumentType", "reportCount": 1, "unique": true, "unitRef": null, "xsiNil": "false" } } }, "segmentCount": 0, "tag": { "dei_AmendmentFlag": { "auth_ref": [], "lang": { "en-US": { "role": { "documentation": "Boolean flag that is true when the XBRL content amends previously-filed or accepted submission.", "label": "Amendment Flag", "terseLabel": "Amendment Flag" } } }, "localname": "AmendmentFlag", "nsuri": "http://xbrl.sec.gov/dei/2019-01-31", "presentation": [ "http://www.epizyme.com//20200504/taxonomy/role/DocumentDocumentAndEntityInformation" ], "xbrltype": "booleanItemType" }, "dei_CityAreaCode": { "auth_ref": [], "lang": { "en-US": { "role": { "documentation": "Area code of city", "label": "City Area Code", "terseLabel": "City Area Code" } } }, "localname": "CityAreaCode", "nsuri": "http://xbrl.sec.gov/dei/2019-01-31", "presentation": [ "http://www.epizyme.com//20200504/taxonomy/role/DocumentDocumentAndEntityInformation" ], "xbrltype": "normalizedStringItemType" }, "dei_CoverAbstract": { "auth_ref": [], "lang": { "en-US": { "role": { "documentation": "Cover page.", "label": "Cover [Abstract]", "terseLabel": "Cover [Abstract]" } } }, "localname": "CoverAbstract", "nsuri": "http://xbrl.sec.gov/dei/2019-01-31", "xbrltype": "stringItemType" }, "dei_DocumentPeriodEndDate": { "auth_ref": [], "lang": { "en-US": { "role": { "documentation": "The end date of the period reflected on the cover page if a periodic report. For all other reports and registration statements containing historical data, it is the date up through which that historical data is presented. If there is no historical data in the report, use the filing date. The format of the date is CCYY-MM-DD.", "label": "Document Period End Date", "terseLabel": "Document Period End Date" } } }, "localname": "DocumentPeriodEndDate", "nsuri": "http://xbrl.sec.gov/dei/2019-01-31", "presentation": [ "http://www.epizyme.com//20200504/taxonomy/role/DocumentDocumentAndEntityInformation" ], "xbrltype": "dateItemType" }, "dei_DocumentType": { "auth_ref": [], "lang": { "en-US": { "role": { "documentation": "The type of document being provided (such as 10-K, 10-Q, 485BPOS, etc). The document type is limited to the same value as the supporting SEC submission type, or the word 'Other'.", "label": "Document Type", "terseLabel": "Document Type" } } }, "localname": "DocumentType", "nsuri": "http://xbrl.sec.gov/dei/2019-01-31", "presentation": [ "http://www.epizyme.com//20200504/taxonomy/role/DocumentDocumentAndEntityInformation" ], "xbrltype": "submissionTypeItemType" }, "dei_EntityAddressAddressLine1": { "auth_ref": [], "lang": { "en-US": { "role": { "documentation": "Address Line 1 such as Attn, Building Name, Street Name", "label": "Entity Address, Address Line One", "terseLabel": "Entity Address, Address Line One" } } }, "localname": "EntityAddressAddressLine1", "nsuri": "http://xbrl.sec.gov/dei/2019-01-31", "presentation": [ "http://www.epizyme.com//20200504/taxonomy/role/DocumentDocumentAndEntityInformation" ], "xbrltype": "normalizedStringItemType" }, "dei_EntityAddressCityOrTown": { "auth_ref": [], "lang": { "en-US": { "role": { "documentation": "Name of the City or Town", "label": "Entity Address, City or Town", "terseLabel": "Entity Address, City or Town" } } }, "localname": "EntityAddressCityOrTown", "nsuri": "http://xbrl.sec.gov/dei/2019-01-31", "presentation": [ "http://www.epizyme.com//20200504/taxonomy/role/DocumentDocumentAndEntityInformation" ], "xbrltype": "normalizedStringItemType" }, "dei_EntityAddressPostalZipCode": { "auth_ref": [], "lang": { "en-US": { "role": { "documentation": "Code for the postal or zip code", "label": "Entity Address, Postal Zip Code", "terseLabel": "Entity Address, Postal Zip Code" } } }, "localname": "EntityAddressPostalZipCode", "nsuri": "http://xbrl.sec.gov/dei/2019-01-31", "presentation": [ "http://www.epizyme.com//20200504/taxonomy/role/DocumentDocumentAndEntityInformation" ], "xbrltype": "normalizedStringItemType" }, "dei_EntityAddressStateOrProvince": { "auth_ref": [], "lang": { "en-US": { "role": { "documentation": "Name of the state or province.", "label": "Entity Address, State or Province", "terseLabel": "Entity Address, State or Province" } } }, "localname": "EntityAddressStateOrProvince", "nsuri": "http://xbrl.sec.gov/dei/2019-01-31", "presentation": [ "http://www.epizyme.com//20200504/taxonomy/role/DocumentDocumentAndEntityInformation" ], "xbrltype": "stateOrProvinceItemType" }, "dei_EntityCentralIndexKey": { "auth_ref": [ "r5" ], "lang": { "en-US": { "role": { "documentation": "A unique 10-digit SEC-issued value to identify entities that have filed disclosures with the SEC. It is commonly abbreviated as CIK.", "label": "Entity Central Index Key", "terseLabel": "Entity Central Index Key" } } }, "localname": "EntityCentralIndexKey", "nsuri": "http://xbrl.sec.gov/dei/2019-01-31", "presentation": [ "http://www.epizyme.com//20200504/taxonomy/role/DocumentDocumentAndEntityInformation" ], "xbrltype": "centralIndexKeyItemType" }, "dei_EntityEmergingGrowthCompany": { "auth_ref": [ "r5" ], "lang": { "en-US": { "role": { "documentation": "Indicate if registrant meets the emerging growth company criteria.", "label": "Entity Emerging Growth Company", "terseLabel": "Entity Emerging Growth Company" } } }, "localname": "EntityEmergingGrowthCompany", "nsuri": "http://xbrl.sec.gov/dei/2019-01-31", "presentation": [ "http://www.epizyme.com//20200504/taxonomy/role/DocumentDocumentAndEntityInformation" ], "xbrltype": "booleanItemType" }, "dei_EntityFileNumber": { "auth_ref": [], "lang": { "en-US": { "role": { "documentation": "Commission file number. The field allows up to 17 characters. The prefix may contain 1-3 digits, the sequence number may contain 1-8 digits, the optional suffix may contain 1-4 characters, and the fields are separated with a hyphen.", "label": "Entity File Number", "terseLabel": "Entity File Number" } } }, "localname": "EntityFileNumber", "nsuri": "http://xbrl.sec.gov/dei/2019-01-31", "presentation": [ "http://www.epizyme.com//20200504/taxonomy/role/DocumentDocumentAndEntityInformation" ], "xbrltype": "fileNumberItemType" }, "dei_EntityIncorporationStateCountryCode": { "auth_ref": [], "lang": { "en-US": { "role": { "documentation": "Two-character EDGAR code representing the state or country of incorporation.", "label": "Entity Incorporation State Country Code", "terseLabel": "Entity Incorporation State Country Code" } } }, "localname": "EntityIncorporationStateCountryCode", "nsuri": "http://xbrl.sec.gov/dei/2019-01-31", "presentation": [ "http://www.epizyme.com//20200504/taxonomy/role/DocumentDocumentAndEntityInformation" ], "xbrltype": "edgarStateCountryItemType" }, "dei_EntityRegistrantName": { "auth_ref": [ "r5" ], "lang": { "en-US": { "role": { "documentation": "The exact name of the entity filing the report as specified in its charter, which is required by forms filed with the SEC.", "label": "Entity Registrant Name", "terseLabel": "Entity Registrant Name" } } }, "localname": "EntityRegistrantName", "nsuri": "http://xbrl.sec.gov/dei/2019-01-31", "presentation": [ "http://www.epizyme.com//20200504/taxonomy/role/DocumentDocumentAndEntityInformation" ], "xbrltype": "normalizedStringItemType" }, "dei_EntityTaxIdentificationNumber": { "auth_ref": [ "r5" ], "lang": { "en-US": { "role": { "documentation": "The Tax Identification Number (TIN), also known as an Employer Identification Number (EIN), is a unique 9-digit value assigned by the IRS.", "label": "Entity Tax Identification Number", "terseLabel": "Entity Tax Identification Number" } } }, "localname": "EntityTaxIdentificationNumber", "nsuri": "http://xbrl.sec.gov/dei/2019-01-31", "presentation": [ "http://www.epizyme.com//20200504/taxonomy/role/DocumentDocumentAndEntityInformation" ], "xbrltype": "employerIdItemType" }, "dei_LocalPhoneNumber": { "auth_ref": [], "lang": { "en-US": { "role": { "documentation": "Local phone number for entity.", "label": "Local Phone Number", "terseLabel": "Local Phone Number" } } }, "localname": "LocalPhoneNumber", "nsuri": "http://xbrl.sec.gov/dei/2019-01-31", "presentation": [ "http://www.epizyme.com//20200504/taxonomy/role/DocumentDocumentAndEntityInformation" ], "xbrltype": "normalizedStringItemType" }, "dei_PreCommencementIssuerTenderOffer": { "auth_ref": [ "r2" ], "lang": { "en-US": { "role": { "documentation": "Boolean flag that is true when the Form 8-K filing is intended to satisfy the filing obligation of the registrant as pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act.", "label": "Pre Commencement Issuer Tender Offer", "terseLabel": "Pre Commencement Issuer Tender Offer" } } }, "localname": "PreCommencementIssuerTenderOffer", "nsuri": "http://xbrl.sec.gov/dei/2019-01-31", "presentation": [ "http://www.epizyme.com//20200504/taxonomy/role/DocumentDocumentAndEntityInformation" ], "xbrltype": "booleanItemType" }, "dei_PreCommencementTenderOffer": { "auth_ref": [ "r3" ], "lang": { "en-US": { "role": { "documentation": "Boolean flag that is true when the Form 8-K filing is intended to satisfy the filing obligation of the registrant as pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act.", "label": "Pre Commencement Tender Offer", "terseLabel": "Pre Commencement Tender Offer" } } }, "localname": "PreCommencementTenderOffer", "nsuri": "http://xbrl.sec.gov/dei/2019-01-31", "presentation": [ "http://www.epizyme.com//20200504/taxonomy/role/DocumentDocumentAndEntityInformation" ], "xbrltype": "booleanItemType" }, "dei_Security12bTitle": { "auth_ref": [ "r0" ], "lang": { "en-US": { "role": { "documentation": "Title of a 12(b) registered security.", "label": "Security 12b Title", "terseLabel": "Security 12b Title" } } }, "localname": "Security12bTitle", "nsuri": "http://xbrl.sec.gov/dei/2019-01-31", "presentation": [ "http://www.epizyme.com//20200504/taxonomy/role/DocumentDocumentAndEntityInformation" ], "xbrltype": "securityTitleItemType" }, "dei_SecurityExchangeName": { "auth_ref": [ "r1" ], "lang": { "en-US": { "role": { "documentation": "Name of the Exchange on which a security is registered.", "label": "Security Exchange Name", "terseLabel": "Security Exchange Name" } } }, "localname": "SecurityExchangeName", "nsuri": "http://xbrl.sec.gov/dei/2019-01-31", "presentation": [ "http://www.epizyme.com//20200504/taxonomy/role/DocumentDocumentAndEntityInformation" ], "xbrltype": "edgarExchangeCodeItemType" }, "dei_SolicitingMaterial": { "auth_ref": [ "r4" ], "lang": { "en-US": { "role": { "documentation": "Boolean flag that is true when the Form 8-K filing is intended to satisfy the filing obligation of the registrant as soliciting material pursuant to Rule 14a-12 under the Exchange Act.", "label": "Soliciting Material", "terseLabel": "Soliciting Material" } } }, "localname": "SolicitingMaterial", "nsuri": "http://xbrl.sec.gov/dei/2019-01-31", "presentation": [ "http://www.epizyme.com//20200504/taxonomy/role/DocumentDocumentAndEntityInformation" ], "xbrltype": "booleanItemType" }, "dei_TradingSymbol": { "auth_ref": [], "lang": { "en-US": { "role": { "documentation": "Trading symbol of an instrument as listed on an exchange.", "label": "Trading Symbol", "terseLabel": "Trading Symbol" } } }, "localname": "TradingSymbol", "nsuri": "http://xbrl.sec.gov/dei/2019-01-31", "presentation": [ "http://www.epizyme.com//20200504/taxonomy/role/DocumentDocumentAndEntityInformation" ], "xbrltype": "tradingSymbolItemType" }, "dei_WrittenCommunications": { "auth_ref": [ "r6" ], "lang": { "en-US": { "role": { "documentation": "Boolean flag that is true when the Form 8-K filing is intended to satisfy the filing obligation of the registrant as written communications pursuant to Rule 425 under the Securities Act.", "label": "Written Communications", "terseLabel": "Written Communications" } } }, "localname": "WrittenCommunications", "nsuri": "http://xbrl.sec.gov/dei/2019-01-31", "presentation": [ "http://www.epizyme.com//20200504/taxonomy/role/DocumentDocumentAndEntityInformation" ], "xbrltype": "booleanItemType" } }, "unitCount": 0 } }, "std_ref": { "r0": { "Name": "Exchange Act", "Number": "240", "Publisher": "SEC", "Section": "12", "Subsection": "b" }, "r1": { "Name": "Exchange Act", "Number": "240", "Publisher": "SEC", "Section": "12", "Subsection": "d1-1" }, "r2": { "Name": "Exchange Act", "Number": "240", "Publisher": "SEC", "Section": "13e", "Subsection": "4c" }, "r3": { "Name": "Exchange Act", "Number": "240", "Publisher": "SEC", "Section": "14d", "Subsection": "2b" }, "r4": { "Name": "Exchange Act", "Number": "240", "Publisher": "SEC", "Section": "14a", "Subsection": "12" }, "r5": { "Name": "Regulation 12B", "Number": "240", "Publisher": "SEC", "Section": "12", "Subsection": "b-2" }, "r6": { "Name": "Securities Act", "Number": "230", "Publisher": "SEC", "Section": "425" } }, "version": "2.1" } ZIP 7 0001193125-20-131670-xbrl.zip IDEA: XBRL DOCUMENT begin 644 0001193125-20-131670-xbrl.zip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end XML 8 Show.js IDEA: XBRL DOCUMENT // Edgar(tm) Renderer was created by staff of the U.S. Securities and Exchange Commission. Data and content created by government employees within the scope of their employment are not subject to domestic copyright protection. 17 U.S.C. 105. var Show={};Show.LastAR=null,Show.showAR=function(a,r,w){if(Show.LastAR)Show.hideAR();var e=a;while(e&&e.nodeName!='TABLE')e=e.nextSibling;if(!e||e.nodeName!='TABLE'){var ref=((window)?w.document:document).getElementById(r);if(ref){e=ref.cloneNode(!0); e.removeAttribute('id');a.parentNode.appendChild(e)}} if(e)e.style.display='block';Show.LastAR=e};Show.hideAR=function(){Show.LastAR.style.display='none'};Show.toggleNext=function(a){var e=a;while(e.nodeName!='DIV')e=e.nextSibling;if(!e.style){}else if(!e.style.display){}else{var d,p_;if(e.style.display=='none'){d='block';p='-'}else{d='none';p='+'} e.style.display=d;if(a.textContent){a.textContent=p+a.textContent.substring(1)}else{a.innerText=p+a.innerText.substring(1)}}} XML 10 report.css IDEA: XBRL DOCUMENT /* Updated 2009-11-04 */ /* v2.2.0.24 */ /* DefRef Styles */ ..report table.authRefData{ background-color: #def; border: 2px solid #2F4497; font-size: 1em; position: absolute; } ..report table.authRefData a { display: block; font-weight: bold; } ..report table.authRefData p { margin-top: 0px; } ..report table.authRefData .hide { background-color: #2F4497; padding: 1px 3px 0px 0px; text-align: right; } ..report table.authRefData .hide a:hover { background-color: #2F4497; } ..report table.authRefData .body { height: 150px; overflow: auto; width: 400px; } ..report table.authRefData table{ font-size: 1em; } /* Report Styles */ ..pl a, .pl a:visited { color: black; text-decoration: none; } /* table */ ..report { background-color: white; border: 2px solid #acf; clear: both; color: black; font: normal 8pt Helvetica, Arial, san-serif; margin-bottom: 2em; } ..report hr { border: 1px solid #acf; } /* Top labels */ ..report th { background-color: #acf; color: black; font-weight: bold; text-align: center; } ..report th.void { background-color: transparent; color: #000000; font: bold 10pt Helvetica, Arial, san-serif; text-align: left; } ..report .pl { text-align: left; vertical-align: top; white-space: normal; width: 200px; white-space: normal; /* word-wrap: break-word; */ } ..report td.pl a.a { cursor: pointer; display: block; width: 200px; overflow: hidden; } ..report td.pl div.a { width: 200px; } ..report td.pl a:hover { background-color: #ffc; } /* Header rows... */ ..report tr.rh { background-color: #acf; color: black; font-weight: bold; } /* Calendars... */ ..report .rc { background-color: #f0f0f0; } /* Even rows... */ ..report .re, .report .reu { background-color: #def; } ..report .reu td { border-bottom: 1px solid black; } /* Odd rows... */ ..report .ro, .report .rou { background-color: white; } ..report .rou td { border-bottom: 1px solid black; } ..report .rou table td, .report .reu table td { border-bottom: 0px solid black; } /* styles for footnote marker */ ..report .fn { white-space: nowrap; } /* styles for numeric types */ ..report .num, .report .nump { text-align: right; white-space: nowrap; } ..report .nump { padding-left: 2em; } ..report .nump { padding: 0px 0.4em 0px 2em; } /* styles for text types */ ..report .text { text-align: left; white-space: normal; } ..report .text .big { margin-bottom: 1em; width: 17em; } ..report .text .more { display: none; } ..report .text .note { font-style: italic; font-weight: bold; } ..report .text .small { width: 10em; } ..report sup { font-style: italic; } ..report .outerFootnotes { font-size: 1em; } XML 11 FilingSummary.xml IDEA: XBRL DOCUMENT 3.20.1 html 1 95 1 false 0 0 false 0 false false R1.htm 100000 - Document - Document and Entity Information Sheet http://www.epizyme.com//20200504/taxonomy/role/DocumentDocumentAndEntityInformation Document and Entity Information Cover 1 false false All Reports Book All Reports d919800d8k.htm d919800dex991.htm epzm-20200504.xsd epzm-20200504_lab.xml epzm-20200504_pre.xml http://xbrl.sec.gov/dei/2019-01-31 true false XML 12 d919800d8k_htm.xml IDEA: XBRL DOCUMENT 0001571498 2020-05-04 2020-05-04 false 0001571498 8-K 2020-05-04 EPIZYME, INC. DE 001-35945 26-1349956 400 Technology Square Cambridge MA 02139 (617) 229-5872 false false false false Common stock, $0.0001 par value EPZM NASDAQ false XML 13 R1.htm IDEA: XBRL DOCUMENT v3.20.1
Document and Entity Information
May 04, 2020
Cover [Abstract]  
Amendment Flag false
Entity Central Index Key 0001571498
Document Type 8-K
Document Period End Date May 04, 2020
Entity Registrant Name EPIZYME, INC.
Entity Incorporation State Country Code DE
Entity File Number 001-35945
Entity Tax Identification Number 26-1349956
Entity Address, Address Line One 400 Technology Square
Entity Address, City or Town Cambridge
Entity Address, State or Province MA
Entity Address, Postal Zip Code 02139
City Area Code (617)
Local Phone Number 229-5872
Written Communications false
Soliciting Material false
Pre Commencement Tender Offer false
Pre Commencement Issuer Tender Offer false
Security 12b Title Common stock, $0.0001 par value
Trading Symbol EPZM
Security Exchange Name NASDAQ
Entity Emerging Growth Company false
EXCEL 14 Financial_Report.xlsx IDEA: XBRL DOCUMENT begin 644 Financial_Report.xlsx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