Exhibit 23.3

Consent of Clarion Healthcare, LLC

Clarion Healthcare, LLC (“Clarion”) hereby consents to the use of its name and the statements attributed to it in the Registration Statement of Epizyme, Inc. on Form S-1, dated April 18, 2013 (and any amendments thereto), provided that any modifications to the use of Clarion’s name or the statements attributed to Clarion in such Registration Statement shall be subject to the prior consent of Clarion.

CLARION HEALTHCARE, LLC
By:	/s/ Daniel J. Hawkins
Name:	Daniel J. Hawkins
Title:	Managing Director

Date:	April 18, 2013
	Boston, MA