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Supplemental Balance Sheet Information - Schedule of Accrued Expenses (Detail) - USD ($)
$ in Thousands
Jun. 30, 2022
Dec. 31, 2021
Accrued Liabilities, Current [Abstract]    
Employee compensation and benefits $ 7,614 $ 11,737
Research and development expenses 10,488 13,744
Current portion of liability related to the sale of future royalties 592 273
Professional services and other 5,977 5,023
Accrued expenses $ 24,671 $ 30,777