Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021
CASH FLOWS FROM OPERATING ACTIVITIES:
Net loss	$ (91,249)	$ (134,637)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	2,580	2,595
Stock-based compensation	9,740	13,733
Amortization of discount on investments	325	665
Amortization of debt discount	424	382
Change in fair value of warrant liability	(1,350)	0
Non-cash royalty revenue related to sale of future royalties	(66)	0
Non-cash interest expense associated with the sale of future royalties	750	967
Changes in operating assets and liabilities:
Accounts receivable	(4,638)	(4,014)
Inventory, current and noncurrent	(1,841)	(6,629)
Prepaid expenses and other current assets	(5,700)	(2,109)
Accounts payable	(5,265)	(2,886)
Accrued expenses	(6,406)	(59)
Deferred revenue	(11,496)	0
Operating lease assets	1,930	2,092
Operating lease liabilities	(1,823)	(2,313)
Other assets and liabilities	87	(33)
Net cash used in operating activities	(113,998)	(132,246)
CASH FLOWS FROM INVESTING ACTIVITIES:
Purchases of available-for-sale securities	(97,418)	(170,659)
Maturities of available-for-sale securities	101,950	211,539
Purchases of property and equipment	(10)	(221)
Net cash used in investing activities	4,522	40,659
CASH FLOWS FROM FINANCING ACTIVITIES:
Proceeds from issuance of common stock, net of commissions	82,257	1,534
Payment of offering costs	(442)	(105)
Proceeds from stock options exercised	0	916
Proceeds from the issuance of shares under employee stock purchase plan	391	1,191
Net cash provided by financing activities	82,206	3,536
Net decrease in cash, cash equivalents and restricted cash	(27,270)	(88,051)
Cash, cash equivalents and restricted cash, beginning of period	99,845	169,724
Cash, cash equivalents and restricted cash, end of period	72,575	81,673
SUPPLEMENTAL CASH FLOW INFORMATION:
Interest paid	10,785	10,785
Cash paid for income taxes	31	0
Unpaid offering costs	0	154
Property and equipment included in accounts payable or accruals	$ 0	$ 18