Condensed Consolidated Statements of Operations and Comprehensive Loss - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021
Revenue:
Total revenue	$ 27,528	$ 13,010	$ 36,224	$ 20,641
Operating expenses:
Cost of revenue	5,169	2,492	7,808	5,346
Research and development	28,054	34,858	57,834	67,561
Selling, general and administrative	24,111	33,891	51,315	70,303
Total operating expenses	57,334	71,241	116,957	143,210
Operating loss	(29,806)	(58,231)	(80,733)	(122,569)
Other (expense) income, net:
Interest expense , net	(5,392)	(5,581)	(10,871)	(11,057)
Other expense (income), net	(166)	(54)	(214)	(44)
Change in fair value of warrants to purchase common stock	0	0	1,350	0
Related party non-cash interest expense related to sale of future royalties	(380)	(497)	(750)	(967)
Other expense, net	(5,938)	(6,132)	(10,485)	(12,068)
Loss before income taxes	(35,744)	(64,363)	(91,218)	(134,637)
Income tax provision	0	0	(31)	0
Net loss	(35,744)	(64,363)	(91,249)	(134,637)
Other comprehensive income (loss):
Unrealized (loss) gain on available-for-sale securities	(61)	(8)	(255)	(5)
Comprehensive loss	$ (35,805)	$ (64,371)	$ (91,504)	$ (134,642)
Net loss per share attributable to common stockholders:
Basic	$ (0.21)	$ (0.63)	$ (0.59)	$ (1.32)
Diluted	$ (0.21)	$ (0.63)	$ (0.59)	$ (1.32)
Weighted-average common shares outstanding used in net loss per share attributable to common stockholders:
Basic	166,990	102,053	155,658	101,922
Diluted	166,990	102,053	155,658	101,922
Product [Member]
Revenue:
Product revenue, net	$ 11,040	$ 7,984	$ 19,696	$ 14,175
Collaboration and Other Revenue [Member]
Revenue:
Collaboration and other revenue	$ 16,488	$ 5,026	$ 16,528	$ 6,466