Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
CASH FLOWS FROM OPERATING ACTIVITIES:
Net loss	$ (55,505)	$ (70,274)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	1,298	1,282
Share-based compensation expense	5,289	7,015
Amortization of discount (premium) on investments	131	363
Amortization of debt discount	208	188
Change in fair value of warrant liability	(1,350)	0
Non-cash royalty revenue related to sale of future royalties	(40)	0
Non-cash interest expense associated with the sale of future royalties	370	470
Changes in operating assets and liabilities:
Accounts receivable	670	(6,659)
Inventory, current and noncurrent	(4,141)	(4,356)
Prepaid expenses and other current assets	1,498	1,028
Accounts payable	(2,566)	(4,816)
Accrued expenses	(4,750)	(4,719)
Deferred revenue	0	5,000
Operating lease assets	767	1,033
Operating lease liabilities	(707)	(1,128)
Other assets and liabilities	(362)	(2)
Net cash used in operating activities	(59,190)	(75,575)
CASH FLOWS FROM INVESTING ACTIVITIES:
Purchases of available-for-sale securities	(91,978)	(120,589)
Maturities of available-for-sale securities	47,800	100,389
Purchases of property and equipment	(10)	(119)
Net cash (used in) provided by investing activities	(44,188)	(20,319)
CASH FLOWS FROM FINANCING ACTIVITIES:
Proceeds from the issuance of shares under employee stock purchase plan	82,257	0
Payment of offering costs	(185)	0
Proceeds from stock options exercised	0	199
Proceeds from the issuance of shares under employee stock purchase plan	391	1,191
Net cash provided by financing activities	82,463	1,390
Net decrease in cash, cash equivalents and restricted cash	(20,915)	(94,504)
Cash, cash equivalents and restricted cash, beginning of period	99,845	169,724
Cash, cash equivalents and restricted cash, end of period	78,930	75,220
SUPPLEMENTAL CASH FLOW INFORMATION:
Interest paid	5,363	5,368
Cash paid for income taxes	31	0
Unpaid offering costs	208	0
Property and equipment included in accounts payable or accruals	$ 0	$ 10