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Percentage of cross-functional reduction of current workforce.

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Cash includes currency on hand as well as demand deposits with banks or financial institutions. It also includes other kinds of accounts that have the general characteristics of demand deposits in that the customer may deposit additional funds at any time and effectively may withdraw funds at any time without prior notice or penalty. Cash equivalents, excluding items classified as marketable securities, include short-term, highly liquid Investments that are both readily convertible to known amounts of cash, and so near their maturity that they present minimal risk of changes in value because of changes in interest rates. Generally, only investments with original maturities of three months or less qualify under that definition. Original maturity means original maturity to the entity holding the investment. For example, both a three-month US Treasury bill and a three-year Treasury note purchased three months from maturity qualify as cash equivalents. However, a Treasury note purchased three years ago does not become a cash equivalent when its remaining maturity is three months. Short-term investments, exclusive of cash equivalents, generally consist of marketable securities intended to be sold within one year (or the normal operating cycle if longer) and may include trading securities, available-for-sale securities, or held-to-maturity securities (if maturing within one year), as applicable.

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A description of the time period when the company made its initial offering of a class of securities.

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- Definition

Cash received from collaborators during the current period.

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The cash inflow from the additional capital contribution to the entity.

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- Definition

The cash inflow from a debt initially having maturity due after one year or beyond the operating cycle, if longer.

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The cash inflow from issuance of callable preferred stock which is identified as being convertible to another type of financial security at the option of the issuer or the holder.

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The cash inflow from the issuance of common stock, preferred stock, treasury stock, stock options, and other types of equity.

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- Definition

The cash inflow from a borrowing supported by a written promise to pay an obligation.

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- Definition

The aggregate costs incurred (1) in a planned search or critical investigation aimed at discovery of new knowledge with the hope that such knowledge will be useful in developing a new product or service, a new process or technique, or in bringing about a significant improvement to an existing product or process; or (2) to translate research findings or other knowledge into a plan or design for a new product or process or for a significant improvement to an existing product or process whether intended for sale or the entity's use, during the reporting period charged to research and development projects, including the costs of developing computer software up to the point in time of achieving technological feasibility, and costs allocated in accounting for a business combination to in-process projects deemed to have no alternative future use.

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The cumulative amount of the reporting entity's undistributed earnings or deficit.

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The aggregate total costs related to selling a firm's product and services, as well as all other general and administrative expenses. Direct selling expenses (for example, credit, warranty, and advertising) are expenses that can be directly linked to the sale of specific products. Indirect selling expenses are expenses that cannot be directly linked to the sale of specific products, for example telephone expenses, Internet, and postal charges. General and administrative expenses include salaries of non-sales personnel, rent, utilities, communication, etc.

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Amount of expenses for special or contractual termination benefits provided to current employees involuntarily terminated under a benefit arrangement associated exit or disposal activities pursuant to an authorized plan. Excludes expenses related to one-time termination benefits, a discontinued operation or an asset retirement obligation.

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Equity impact of the value of new stock issued during the period. Includes shares issued in an initial public offering or a secondary public offering.

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The Company - Additional Information (Detail) - USD ($) $ in Thousands		3 Months Ended
	Aug. 09, 2021	Mar. 31, 2022	Sep. 30, 2021	Mar. 31, 2021	Dec. 31, 2021
Basis Of Presentation [Line Items]
Proceeds from the issuance of shares under employee stock purchase plan		$ 82,257		$ 0
Issuance of common stock, Value		81,828
Proceeds from sale of redeemable convertible preferred stock		$ 76,000
Initial public offering completion date		May 2013
Cash, cash equivalents, and marketable securities		$ 199,700
Accumulated deficit		(1,295,340)			$ (1,239,835)
Selling, general and administrative		27,204		36,411
Research and development		29,781		$ 32,704
RPI Finance Trust (RPI) and BioPharma Credit Investments V (Master) LP and BioPharma Credit PLC (the Lenders) [Member]
Basis Of Presentation [Line Items]
Fund received from collaborators		368,100
RPI Finance Trust [Member]
Basis Of Presentation [Line Items]
Proceeds from the issuance of shares under employee stock purchase plan		150,000
Royalty Pharma and Pharmakon Advisors [Member]
Basis Of Presentation [Line Items]
Aggregate fund, amount		1,650,200
Non-equity funding through collaboration agreement		268,800
BioPharma Credit Investments V Master LP And BioPharma Credit PLC [Member]
Basis Of Presentation [Line Items]
Debt financing received through loan agreement		$ 218,100
Operating Cost Reduction Plan [Member]
Basis Of Presentation [Line Items]
Percentage of cross-functional reduction of current workforce	11.00%	12.00%
Severance and termination costs	$ 2,000	$ 2,500
Selling, general and administrative		1,700	$ 1,600
Research and development		800	$ 400
IPO [Member]
Basis Of Presentation [Line Items]
Issuance of common stock, Value		$ 937,300