X0306 4 2022-03-31 0 0001571498 Epizyme, Inc. EPZM 0001579300 BEVERIDGE, ROY A C/O EPIZYME, INC., 400 TECHNOLOGY SQUARE, 4TH FLOOR CAMBRIDGE MA 02139 1 0 0 0 Common Stock, par value $0.0001 2022-03-31 4 A 0 11413 1.15 A 28115 D The shares were issued to the Reporting Person pursuant to his election under the Issuer's director compensation program to receive such shares in lieu of cash fees of $13,125 for Board services for the first fiscal quarter of 2022. The shares were issued on the last day of the first fiscal quarter and the number of shares was calculated by dividing the cash fees to be paid for the quarter by the closing price of the Issuer's common stock on the last trading day of the quarter. /s/ John Weidenbruch, attorney-in-fact 2022-04-01