X0306 4 2020-06-18 0 0001571498 Epizyme, Inc. EPZM 0001219871 MOTT DAVID M YELLOWSTONE CLUB 405 ANDESITE RIDGE ROAD BIG SKY MT 59716-1000 1 0 0 0 Common Stock, par value $0.0001 2020-06-18 4 J 0 67662 0.00 A 106959 I See Footnote Common Stock, par value $0.0001 20582 D NEA Partners 13, L.P ("NEA 13") made a pro rata distribution for no consideration of shares of Common Stock of the Issuer, to its general partner and its limited partners on June 18, 2020. The David Mott Declaration of Trust dated May 31, 2001 as amended (the "Mott Trust") received 67,662 shares of Common Stock of the Issuer in the distribution by NEA 13 on June 18, 2020. The shares are directly held by Mott Trust. The Reporting Person disclaims beneficial ownership within the meaning of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise of such portion of the Mott Trust shares in which the Reporting Person has no pecuniary interest. /s/ John Weidenbruch, attorney-in-fact 2020-06-22