X0306 4 2019-03-31 0 0001571498 Epizyme, Inc. EPZM 0001306119 Conroy Kevin T 309 LAKEWOOD BLVD MADISON WI 53704 1 0 0 0 Common Stock, par value $0.0001 2019-03-31 4 A 0 897 12.39 A 3775 D Stock Option (Right to Buy) 13.74 2019-05-31 4 A 0 17633 0.00 A 2029-05-30 Common Stock 17633 17633 D The shares were issued to the Reporting Person pursuant to his election under the Company's director compensation program to receive such shares in lieu of cash fees of $11,125 for Board services for the first fiscal quarter of 2019. The shares were issued on the last day of the first fiscal quarter and the number of shares was calculated by dividing the cash fees to be paid for the quarter by the closing price of the Company's common stock on the last trading day of the quarter. This option will vest in full on May 31, 2020, subject to Reporting Person's continued service as a director. In the event of a change in control of the Issuer, the option will become exercisable in full. Exhibit List Exhibit 24 - Power of Attorney /s/ John Weidenbruch, attorney-in-fact 2019-06-07