X0206 3 2017-05-09 1 0001404281 Novus Therapeutics, Inc. NVUS 0001569590 OrbiMed Israel GP Ltd. 89 MEDINAT HAYEHUDIM ST BUILDING E, 11TH FLOOR HERZLIYA L3 4614001 ISRAEL 1 0 1 0 0001569821 OrbiMed Israel BioFund GP Limited Partnership 89 MEDINAT HAYEHUDIM ST BUILDING E, 11TH FLOOR HERZLIYA L3 4614001 ISRAEL 1 0 1 0 Exhibit List: Exhibit 24.1 - Power of Attorney for OrbiMed Israel GP Ltd. Exhibit 24.2 - Power of Attorney for OrbiMed BioFund Limited Partnership This report on Form 3 is jointly filed by OrbiMed Israel GP Ltd. and OrbiMed Israel BioFund GP Limited Partnership. The Reporting Persons have designated a representative, currently Erez Chimovits, to serve on the Issuer's board of directors. This report on Form 3 shall not be deemed an admission that any such entity or person, including the Reporting Persons, is a beneficial owner for the purpose of Section 16 of the Exchange Act, or for any other purpose /s/ Ryan A. Murr, as attorney-in-fact for OrbiMed Israel GP Ltd. 2017-05-11 /s/ Ryan A. Murr, as attorney-in-fact for OrbiMed Israel BioFund Limited Partnership 2017-05-11