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Share-Based Compensation (Tables)
 12 Months Ended
Dec. 31, 2024
Share-Based Payment Arrangement [Abstract]  
Total Stock-Based Compensation Expense
Total share-based compensation expense related to all of the Company’s share-based awards, including stock options and RSUs granted to employees and directors recognized during the years ended December 31, 2024, 2023, and 2022, was comprised of the following (in thousands):
Years Ended December 31,
202420232022
Inventoriable costs$1,904 $1,610 $1,791 
Research and development19,500 15,781 15,387 
Selling, general and administrative42,631 35,441 25,835 
Total share-based compensation expense$64,035 $52,832 $43,013 
Assumptions Used for Calculating Value of Options Granted
The following table describes the assumptions used for calculating the value of options granted during the years ended December 31, 2024, 2023 and 2022:
Years Ended December 31,
202420232022
Dividend yield0 %0 %0 %
Expected volatility
74.2%
74.8-78.0%
78.7-88.7%
Weighted-average risk-free interest rate4.08 %3.92 %2.22 %
Expected term (in years)6.06.05.9
Stock Option Activity
Information regarding the stock options activity, including with respect to grants to employees, directors and consultants under the Amended 2018 Plan as of December 31, 2024, and changes during the year then ended, are summarized as follows:
Number of
Shares 		Weighted-
Average
Exercise
Price		Weighted-
Average
Contractual
Life
Outstanding at December 31, 20234,239,982$28.22 5.2 years
Options granted 202434,53971.33 
Options exercised 2024(1,164,610)21.26 
Options canceled 2024(11,896)49.85 
Options expired 2024—— 
Outstanding at December 31, 20243,098,015$31.23 4.9 years
Vested and expected to vest at December 31, 20243,098,015$31.23 
Exercisable at December 31, 20242,745,262$28.39 4.6 years
The following table details the value of options during the years ended December 31, 2024, 2023 and 2022 (in thousands):
Years Ended December 31,
202420232022
Intrinsic value of options exercised
$61,830 $27,187 $48,267 
Intrinsic value of options outstanding
161,995184,027 130,078 
Intrinsic value of options exercisable
151,353166,820 118,340 
Fair value of shares vested
15,36319,120 17,145 
Summary of Information Regarding RSU Activity
Information regarding time based RSU activity, including with respect to grants to employees under the Amended 2018 Plan as of December 31, 2024, and changes during the year then ended, is summarized as follows:
Number of
Shares 		Weighted-
Average
Grant Date
Fair Value Per Share		Weighted-
Average
Contractual
Life
Outstanding at December 31, 20231,645,130$48.92 1.0 years
Time based RSUs granted in 20241,178,61268.82 
Time based RSUs vested in 2024(745,401)47.32 
Time based RSUs cancelled in 2024(76,391)58.85 
Outstanding at December 31, 20242,001,950$60.85 1.0 years
The following table details the value of time based RSUs during the years ended December 31, 2024, 2023 and 2022 (in thousands):
Years Ended December 31,
202420232022
Intrinsic value of time based RSUs outstanding
167,203 117,824 67,455 
Fair value of RSUs vested
35,275 24,400 17,873