Insider Trading Arrangements	3 Months Ended	6 Months Ended
	Jun. 30, 2023 shares	Jun. 30, 2023 shares
Trading Arrangements, by Individual
Non-Rule 10b5-1 Arrangement Adopted	false
Rule 10b5-1 Arrangement Terminated	false
Non-Rule 10b5-1 Arrangement Terminated	false
Michael I. Halstead [Member]
Trading Arrangements, by Individual
Material Terms of Trading Arrangement		•On May 8, 2023, Michael I. Halstead, Executive Vice President, General Counsel and Secretary, modified his Rule 10b5-1 Trading Plan, originally adopted on March 15, 2023, to change the start date of the plan to January 2, 2024, and reduce the number of shares to be sold under the plan. The modified plan is intended to satisfy the affirmative defense of Rule 10b5-1(c) and provides for the sale of up to an aggregate of 37,872 shares of our common stock until March 28, 2024.
Name	Michael I. Halstead
Title	Executive Vice President, General Counsel and Secretary,
Rule 10b5-1 Arrangement Adopted	true
Adoption Date	May 8, 2023
Arrangement Duration	86 days
Aggregate Available	37,872	37,872
Sharon Mates [Member]
Trading Arrangements, by Individual
Material Terms of Trading Arrangement		On June 9, 2023, Sharon Mates, Ph.D., Chairman, President and Chief Executive Officer, modified her Rule 10b5-1 Trading Plan, originally adopted on March 14, 2023, to change the start date to September 18, 2023 and the end date of the plan to May 31, 2024, and reduce the number of shares to be sold under the plan. The modified plan is intended to satisfy the affirmative defense of Rule 10b5-1(c) and provides for the sale of up to an aggregate of 402,337 shares of our common stock including the potential sale of up to 191,362 shares of our common stock upon the exercise of stock options with an exercise expiration date of June 30, 2024. Furthermore, we expect a significant portion of the proceeds from any sales under the plan will be used to cover Dr. Mates' tax liability arising from such sales.
Name	Sharon Mates
Title	Chairman, President and Chief Executive Officer
Rule 10b5-1 Arrangement Adopted	true
Adoption Date	June 9, 2023
Arrangement Duration	256 days
Aggregate Available	402,337	402,337