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Share-Based Compensation
 6 Months Ended
Jun. 30, 2023
Share-Based Payment Arrangement [Abstract]  
Share-Based Compensation Share-Based Compensation
Total share-based compensation expense related to all of the Company's share-based awards, including stock options and restricted stock units (RSUs) granted to employees and directors recognized during the six-month periods ended June 30, 2023 and 2022, was comprised of the following (in thousands):
Six Months Ended June 30,
20232022
Inventoriable costs$762 $824 
Selling, general and administrative15,705 12,224 
Research and development7,198 7,055 
Total share-based compensation expense$23,665 $20,103 
Information regarding the stock options activity, including with respect to grants to employees and directors as of June 30, 2023, and changes during the six-month period then ended, are summarized as follows:
Number of
Shares		Weighted-
Average
Exercise
Price		Weighted-
Average
Contractual
Life
Outstanding at December 31, 20224,785,972$26.27 5.8 years
Options granted 2023275,420
Options exercised 2023(510,274)
Options canceled or expired 2023(35,930)
Outstanding at June 30, 20234,515,188$27.62 
Vested and expected to vest at June 30, 20234,515,188$27.62 
Exercisable at June 30, 20233,739,052$23.18 
The fair value of the time-based RSUs is based on the closing price of the Company’s common stock on the date of grant. Information regarding the time-based RSU activity and changes during the six-month period ended June 30, 2023 is summarized as follows:
Number of
Shares		Weighted-Average
Grant Date
Fair Value Per Share		Weighted-
Average
Contractual
Life
Outstanding at December 31, 20221,274,664$42.76 0.8 years
Time-based RSUs granted in 20231,056,867
Time-based RSUs vested in 2023(655,204)
Time-based RSUs cancelled in 2023(50,056)
Outstanding at June 30, 20231,626,271$48.62 
As of June 30, 2023, there was approximately $68.5 million of unrecognized compensation costs estimated related to unvested time-based RSUs.