X0306 4 2021-05-27 0 0001567514 Intra-Cellular Therapies, Inc. ITCI 0001299430 Alafi Christopher D C/O ALAFI CAPITAL COMPANY, LLC 8 ADMIRAL DRIVE, SUITE 324 EMERYVILLE CA 94608 1 0 0 0 Common Stock 2021-05-27 4 S 0 8482 40.01 D 133843 I Held by Christopher D Alafi Family Trust Common Stock 2021-05-28 4 S 0 38843 40.12 D 95000 I Held by Christopher D Alafi Family Trust Common Stock 346795 D Common Stock 4743770 I Held by Alafi Capital Company, LLC Common Stock 503753 I Held as Trustee of The Moshe H. Alafi and Margaret E. Alafi Generation-Skipping Trust This sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on March 15, 2021. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $40.00 to $40.03, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, on request, full information regarding the number of shares sold at each separate price within the range set forth above. Shireen Michele Alafi is the Trustee of the Christopher D Alafi Family Trust. Dr. Alafi disclaims beneficial ownership of the securities held by the trust except to the extent of his pecuniary interest therein, if any. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $40.005 to $40.31, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, on request, full information regarding the number of shares sold at each separate price within the range set forth above. Dr. Alafi is a managing partner of Alafi Capital Company, LLC and may be deemed to beneficially own the shares held by Alafi Capital Company, LLC. Dr. Alafi disclaims beneficial ownership of the securities held by Alafi Capital Company, LLC except to the extent of his pecuniary interest therein. Dr. Alafi is the Trustee of The Moshe H. Alafi and Margaret E. Alafi Generation-Skipping Trust. Dr. Alafi disclaims beneficial ownership of the securities held by the trust except to the extent of his pecuniary interest therein, if any. /s/ Lawrence J. Hineline, Attorney-in-fact 2021-05-28