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Related Party Transactions (Details Textual) - USD ($)
3 Months Ended 9 Months Ended
Sep. 30, 2018
Sep. 30, 2017
Sep. 30, 2018
Sep. 30, 2017
Dec. 31, 2017
Related Party Transaction [Line Items]          
Stock compensation expense recognized     $ 753,000 $ 1,862,000  
Ownership interest 30.00%   30.00%    
Providence Therapeutics, Inc [Member] | Research Collaboration and License Agreement [Member]          
Related Party Transaction [Line Items]          
Revenue related to amortization of upfront payment $ 400,000 $ 100,000 $ 500,000 $ 900,000  
Accounts receivable, outstanding $ 0   $ 0   $ 0
Stock compensation expense recognized   $ 1,500,000      
Providence Therapeutics, Inc [Member] | Research Collaboration and License Agreement [Member] | President and Chief Executive Officer [Member]          
Related Party Transaction [Line Items]          
Ownership interest 6.40%   6.40%