CONSOLIDATED STATEMENTS OF CHANGES IN MEZZANINE EQUITY AND SHAREHOLDERS' EQUITY - USD ($) $ in Thousands	Total	At-the-market Offering	Common stock	Common stock At-the-market Offering	Additional paid-in capital	Additional paid-in capital At-the-market Offering	Accumulated deficit
Beginning balance (in shares) at Dec. 31, 2020	0
Beginning balance at Dec. 31, 2020	$ 0
Ending balance (in shares) at Dec. 31, 2021	0
Ending balance at Dec. 31, 2021	$ 0
Beginning balance (shares) at Dec. 31, 2020			2,400,290
Beginning balance at Dec. 31, 2020	37,493		$ 4		$ 603,685		$ (566,196)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Net loss	(73,329)						(73,329)
Exercise of options, vesting of restricted stock units and shares under employee stock purchase plan (in shares)			20,274
Exercise of options, vesting of restricted stock units and shares issued under employee stock purchase plan	410				410
Stock-based compensation	8,080				8,080
Issuance of common stock, net of issuance costs (in shares)			293,015	262,962
Issuance of common stock, net of issuance costs	$ 46,824	$ 29,158	$ 1		46,823	$ 29,158
Ending balance (shares) at Dec. 31, 2021	2,976,541		2,976,541
Ending balance at Dec. 31, 2021	$ 48,636		$ 5		688,156		(639,525)
Increase (Decrease) in Temporary Equity [Roll Forward]
Issuance of convertible preferred stock, net of issuance costs (in shares)	3,000
Issuance of convertible preferred stock, net of issuance costs	$ 211
Ending balance (in shares) at Dec. 31, 2022	3,000
Ending balance at Dec. 31, 2022	$ 211
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Net loss	(23,210)						(23,210)
Reclassification due to reverse stock split			$ (5)		5
Exercise of options, vesting of restricted stock units and shares under employee stock purchase plan (in shares)			16,749
Exercise of options, vesting of restricted stock units and shares issued under employee stock purchase plan	9				9
Stock-based compensation	$ 4,297				4,297
Issuance of common stock, net of issuance costs (in shares)				143,770
Issuance of common stock, net of issuance costs		$ 1,470				$ 1,470
Issuance of commitment shares (in shares)			92,644
Ending balance (shares) at Dec. 31, 2022	3,229,704		3,229,704
Ending balance at Dec. 31, 2022	$ 31,202		$ 0		$ 693,937		$ (662,735)