NATURE OF OPERATIONS (Details)						3 Months Ended		12 Months Ended
	Mar. 31, 2022 USD ($) shares	Mar. 15, 2022 USD ($)	Jan. 12, 2022 USD ($)	Aug. 06, 2021 USD ($)	Feb. 12, 2021 shares	Mar. 31, 2022 USD ($) segment shares	Mar. 31, 2021 USD ($)	Dec. 31, 2021 USD ($) employee shares	Feb. 11, 2021 shares
Deferred Compensation Arrangement with Individual, Share-based Payments [Line Items]
Number of segments | segment						1
Period of closing transaction			1 year
Disposal group, milestone payments receivable upon achievement of net sales			$ 450,000,000
Milestone payments upon achieving certain criteria, exceeding annual net sales			$ 100,000,000
Reverse stock split, conversion ratio (share/share)					0.25
Restructuring and related cost, number of positions eliminated | employee								28
Common stock shares authorized (in shares) | shares	150,000,000				75,000,000	150,000,000		150,000,000
Net income (loss)						$ 4,670,000	$ (20,550,000)
Cash used in operations						(9,975,000)	(12,551,000)
Income (loss) from discontinued operations, net of income taxes						13,364,000	(9,674,000)
Net income (loss)						(8,694,000)	$ (10,876,000)
Cash and investments	$ 51,100,000					51,100,000
Accumulated deficit	(634,855,000)					(634,855,000)		$ (639,525,000)
Additional paid-in capital	690,580,000					690,580,000		$ 688,156,000
Outstanding debt	0					0
Sale of stock, public float threshold	75,000,000					75,000,000
Lincoln Park Equity Purchase Agreement
Deferred Compensation Arrangement with Individual, Share-based Payments [Line Items]
Consideration receivable on transaction	$ 30,000,000	$ 30,000,000				30,000,000
Term of equity purchase agreement	36 months	36 months
Menlo - Premerger
Deferred Compensation Arrangement with Individual, Share-based Payments [Line Items]
Common stock shares authorized (in shares) | shares									300,000,000
MST Franchise | Discontinued Operations, Disposed of by Sale
Deferred Compensation Arrangement with Individual, Share-based Payments [Line Items]
Cash proceeds	$ 20,000,000					20,000,000
Additional paid-in capital	$ 5,000,000					$ 5,000,000
Licensing Agreements
Deferred Compensation Arrangement with Individual, Share-based Payments [Line Items]
Payments for licensing agreements				$ 1,000,000
Royalty percent, maximum				10.00%
Topical BETi Option Agreement
Deferred Compensation Arrangement with Individual, Share-based Payments [Line Items]
Payments for licensing agreements				$ 500,000
Milestone payments upon achieving certain criteria, maximum				15,750,000
Oral BETi Option Agreement
Deferred Compensation Arrangement with Individual, Share-based Payments [Line Items]
Payments for licensing agreements				4,000,000
Milestone payments upon achieving certain criteria, maximum				$ 43,750,000