JEFFERIES LLC

520 Madison Avenue

New York, New York 10022

PIPER JAFFRAY & CO

50 California Street, Suite 3100

San Francisco, California 94111

GUGGENHEIM SECURITIES, LLC

330 Madison Avenue

New York, New York 10017

VIA EDGAR January 22, 2018

U.S. Securities and Exchange Commission

Division of Corporation Finance

100 F. Street, N.E. Washington, D.C. 20549-3628

Attention:	Christine Torney
	Jim Rosenberg
	Chris Edwards
	Erin Jaskot
	Re:	Menlo Therapeutics Inc. Registration Statement on Form S-1
		File No. 333-222324
		Acceleration Request

Ladies and Gentlemen:

As representatives of the several underwriters of the proposed public offering of 7,500,000 shares of common stock of Menlo Therapeutics Inc. (the “Company”), we hereby join the Company’s request to accelerate the date of the above-referenced Registration Statement, as then amended, effective as of 4:30 p.m. (New York time) on January 24, 2018, or as soon thereafter as is practicable.

Pursuant to Rule 460 under the Securities Act of 1933, as amended, we wish to advise you that we have distributed approximately 705 copies of the Company’s preliminary prospectus, dated January 12, 2018, through the date hereof, to underwriters, dealers, institutions and others. The undersigned have been informed by the participating underwriters that they have complied and will continue to comply with Rule 15c2-8 under the Securities Exchange Act of 1934, as amended.

(Signature Page Follows)

Very truly yours,
JEFFERIES LLC PIPER JAFFRAY & CO GUGGENHEIM SECURITIES, LLC As representatives of the several underwriters
By:	JEFFERIES LLC
By:	/s/ Michael Brinkman
	Name: Michael Brinkman
	Title: Managing Director
By:	PIPER JAFFRAY & CO
By:	/s/ Christie L. Christina
	Name: Christie L. Christina
	Title: Managing Director
By:	GUGGENHEIM SECURITIES, LLC
By:	/s/ Shiv Taylor
	Name: Shiv Taylor
	Title: Senior Managing Director

[Signature Page – Acceleration Request]