X0508 4 2023-12-13 0 0001566044 VYNE Therapeutics Inc. VYNE 0001374180 Bruno Anthony D C/O VYNE THERAPEUTICS INC. 685 ROUTE 202/206 N, SUITE 301 BRIDGEWATER NJ 08807 1 0 0 0 0 Stock Option (right to buy) 2.70 2023-12-13 4 A 0 20000 0.00 A 2033-12-12 Common Stock 20000 20000 D Represents the annual award to non-employee directors of the Issuer, awarded on the date of the Issuer's annual meeting of stockholders. These options vest on December 13, 2024, subject to the Reporting Person's continuous service through such date. /s/ Mutya Harsch, attorney-in-fact for Anthony D. Bruno 2023-12-15