X0206 3 2023-11-01 0 0001566044 VYNE Therapeutics Inc. VYNE 0001942670 AI Biotechnology LLC C/O ACCESS INDUSTRIES, INC. 40 WEST 57TH STREET, 28TH FLOOR NEW YORK NY 10019 0 0 1 0 0001391297 Access Industries Holdings LLC C/O ACCESS INDUSTRIES, INC. 40 WEST 57TH STREET, 28TH FL NEW YORK NY 10019 0 0 1 0 0001508226 ACCESS INDUSTRIES MANAGEMENT, LLC C/O ACCESS INDUSTRIES, INC. 40 WEST 57TH STREET, 28TH FLOOR NEW YORK NY 10019 0 0 1 0 0001326628 Blavatnik Len C/O ACCESS INDUSTRIES, INC. 40 WEST 57TH STREET, 28TH FL NEW YORK NY 10019 0 0 1 0 Common Stock 1116585 D Warrant (right to buy) 0.0001 Common Stock 7792448 D The securities reported are held directly by AI Biotechnology LLC ("AI Biotechnology") and may be deemed to be beneficially owned by Access Industries Holdings LLC ("AIH"), Access Industries Management, LLC ("AIM") and Len Blavatnik because (i) Mr. Blavatnik controls AIM and AIH, (ii) AIM controls AIH, and (iii) AIH owns all of the voting units of AI Biotechnology. Each of the reporting persons (other than AI Biotechnology) disclaims beneficial ownership of these securities, except to the extent of its or his pecuniary interest therein, and this form shall not be construed as an admission that any such reporting person is the beneficial owner of any of the securities reported on this form. Each pre-funded warrant is exercisable at any time after the date of issuance and the pre-funded warrants do not expire. The pre-funded warrants are not exercisable to the extent that the aggregate number of shares of Common Stock beneficially owned by AI Biotechnology immediately following such exercise would exceed 9.99%; provided, however, that AI Biotechnology may increase or decrease the beneficial ownership limitation by giving 60 days' notice to the Issuer, but not to exceed any percentage in excess of 19.99%. Exhibit List: Ex.24 - Power of Attorney /s/ Alejandro Moreno for AI Biotechnology LLC 2023-11-13 /s/ Alejandro Moreno for Access Industries Holdings LLC 2023-11-13 /s/ Alejandro Moreno for Access Industries Management, LLC 2023-11-13 /s/ Alejandro Moreno as Attorney-in-Fact for Mr. Blavatnik 2023-11-13