X0407 4 2023-05-31 0 0001566044 VYNE Therapeutics Inc. VYNE 0001727809 Harsch Mutya C/O VYNE THERAPEUTICS INC. 685 ROUTE 202/206 N, SUITE 301 BRIDGEWATER NJ 08807 0 1 0 0 Chief Legal Officer and GC 0 Common Stock 2023-05-31 5 A 0 E 3664 3.4563 A 25907 D These shares were acquired under the Issuer's Employee Share Purchase Plan ("ESPP") for the ESPP purchase period beginning on December 1, 2022 and ending on May 31, 2023 in transactions that were exempt under both Rule 16b-3(d) and Rule 16b-3(c). In accordance with the terms of the ESPP, these shares were purchased at a price equal to 85% of the fair market value closing price of the Issuer's common stock on December 1, 2022. /s/ Mutya Harsch 2023-06-02