X0407 4 2023-03-20 0 0001566044 VYNE Therapeutics Inc. VYNE 0001055404 LEPORE PATRICK G C/O VYNE THERAPEUTICS INC. 685 ROUTE 202/206, SUITE 301A BRIDGEWATER NJ 08807 1 0 0 0 0 Common Stock 2023-03-20 4 P 0 20000 2.484 A 23472 D The price reported is a weighted average purchase price. The shares were purchased in multiple transactions at prices ranging from $2.464 to $2.5199, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer or the staff of the Securities Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote. On February 10, 2023, the Issuer effected a one-for-18 reverse split of its Common Stock. The number of securities reported reflects the reverse split. /s/ Mutya Harsch, as attorney-in-fact for Patrick G. LePore 2023-03-22