X0306 4 2022-11-30 0 0001566044 VYNE Therapeutics Inc. VYNE 0001727794 Domzalski David C/O VYNE THERAPEUTICS INC. 685 ROUTE 202/206, SUITE 301A BRIDGEWATER NJ 08807 1 1 0 0 President and CEO Common Stock 2022-11-30 5 A 0 E 34705 0.1977 A 1074975 D These shares were acquired under the Issuer's Employee Share Purchase Plan ("ESPP") for the ESPP purchase period beginning on June 1, 2022 and ending on November 30, 2022 in transactions that were exempt under both Rule 16b-3(d) and Rule 16b-3(c). In accordance with the terms of the ESPP, these shares were purchased at a price equal to 85% of the fair market value closing price of the Issuer's ordinary shares on November 30, 2022 (the last trading day of the offering period). The reporting person purchased the maximum number of shares permitted by the terms of the ESPP during the calendar year. /s/ Mutya Harsch, attorney-in-fact for David Domzalski 2022-12-02