X0306 4 2020-09-08 0 0001566044 VYNE Therapeutics Inc. VYNE 0001727794 Domzalski David 520 U.S. HIGHWAY 22, SUITE 204 BRIDGEWATER NJ 08807 1 1 0 0 President and CEO Common Stock 2020-09-08 4 P 0 75000 1.3809 A 1315966 D These shares were purchased in multiple transactions at prices ranging from $1.34 to $1.48 inclusive. The reporting person undertakes to provide the issuer, any security holder of the issuer or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth above. /s/ Mutya Harsch, attorney-in-fact for David Domzalski 2020-09-08