Stockholders' Equity (Details Narrative)									12 Months Ended
	Nov. 16, 2017 $ / shares shares	Sep. 11, 2017 USD ($) shares	Aug. 18, 2017 USD ($) shares	Jul. 01, 2017 $ / shares shares	May 19, 2017 USD ($) shares	Mar. 24, 2017 $ / shares shares	Mar. 15, 2017 shares	Feb. 14, 2017 USD ($) $ / shares shares	Dec. 31, 2018 USD ($) $ / shares shares	Dec. 31, 2017 USD ($) $ / shares shares	Dec. 31, 2016 shares
Number of common stock issued under compensation, value | $									$ 160,407
Compensation cost | $									$ 3,728,154
Number of common stock shares issued to related party obligations									429,585
Number of common stock shares issued to related party obligations, value | $									$ 240,000
Number of shares issued on conversion									775,184
Number of shares issued on conversion, value | $									$ 2,338,758
Beneficial conversion feature amount | $									193,877
Increase in the value of beneficial conversion feature | $									$ 284,000
Common stock draw down description									In connection with its 2017 Annual Meeting of Stockholders held on June 15, 2017, the Company did not receive stockholder approval, as required pursuant to Nasdaq Marketplace Rule 5635(d), to issue shares of common stock under the Lincoln Park Purchase Agreement in an amount equal to 20% or more of the Company's outstanding shares of common stock. As such, the Company will not be permitted to draw down the full $15,000,000 in shares of common stock under the Lincoln Park Purchase Agreement unless and until the Company receives such stockholder approval.
Sharebased compensation shares cancelled											1,844
Shaebased compensation options granted						3,555,500			220,000
Share-based compensation requisite service period						10 years
Stock option, exercise price | $ / shares						$ 1.55
Stock option related to Vesting of Remaining Options for Terminated Employees | $									$ 800,000
Share-based compensation | $									$ 3,728,000	$ 2,209,000
Weighted average fair value of options granted | $ / shares									$ 0.89	$ 1.58
Weighted average remaining contractual life of option						6 years			8 years 4 months 28 days	8 years 4 months 2 days
Weighted average remaining contractual life, option exercisable									8 years 4 months 2 days
Intrinsic value of options exercisable, per share | $ / shares									$ 0	$ 0
Unrecognized cost of unvested options | $									$ 3,340,000
Remaining amortization period									1 year 8 months 19 days
Number of warrants, Granted									3,200,000
Number of warrants, Forfeited or Expired									(23,460)
Number of warrants, Ending outstanding									11,871,813	8,695,273
Weighted Average Exercise Price, Ending outstanding | $ / shares									$ 1.98	$ 5.50
Measurement Input, Risk Free Interest Rate [Member]
Warrants or rights outstanding measurement inputs	0.0198			0.0184		1.90
Measurement Input, Expected Dividend Rate [Member]
Warrants or rights outstanding measurement inputs	0.00			0.00		0.00
Measurement Input, Option Volatility [Member]
Warrants or rights outstanding measurement inputs	2.8191			2.8393		2.8651
Common Stock [Member]
Number of common stock shares issued under compensation									12,232	104,218
Increase in the value of beneficial conversion feature | $
Number of shares issued			1,560,978
Issuance of common stock | $			$ 3,200,000
WarrantMember
Number of shares issued									780,489
Terminated Employees [Member]
Share-based compensation | $										$ 800,000
Employee Consultant Agreements [Member]
Number of common stock shares issued under compensation									12,232
Number of common stock issued under compensation, value | $									$ 19,081
Accrued Interest on Convertible Promissory Note [Member]
Number of shares issued on conversion									276,796
Number of shares issued on conversion, value | $									$ 180,000
August 2017 Financing [Member]
Stock issued price per share | $ / shares									$ 2.50
Lincoln Park Purchase Agreement [Member]
Number of shares issued		192,431
Issuance of common stock | $					$ 15,000,000
Lincoln Park Purchase Agreement [Member] | General and Administrative Expense [Member]
Issuance of common stock | $		$ 302,000
Lincoln Park Purchase Agreement [Member] | Common Stock [Member]
Number of shares issued					125,000
February 2017 Financing [Member]
Number of shares issued								1,750,000
February 2017 Financing [Member] | WarrantMember
Number of shares issued								1,312,500
Issuance of common stock | $								$ 3,500,000
Stock issued price per share | $ / shares								$ 2.00
Shares Issued for Services [Member]
Number of shares issued										1,772,152
Issuance of common stock | $										$ 3,042,000
2013 Stock Option Plan [Member]
Shaebased compensation options granted							1,135,000
Share-based compensation requisite service period							10 years
2015 Incentive Compensation Plan [Member]
Shaebased compensation options granted							755,500
Share-based compensation requisite service period							10 years
2016 Incentive Compensation Plan [Member]
Shaebased compensation options granted							1,665,000
Share-based compensation requisite service period							10 years
2017 Incentive Compensation Plan [Member]
Shaebased compensation options granted	340,000			2,795,000
Share-based compensation requisite service period	10 years			10 years
Stock option, exercise price | $ / shares	$ 1.54			$ 1.62
Weighted average remaining contractual life of option	6 years			6 years
Employees and Consultants [Member]
Number of common stock shares issued under compensation									2,083,136
Number of common stock issued under compensation, value | $									$ 1,793,336