X0407 4 2023-06-28 0 0001563880 Trevi Therapeutics, Inc. TRVI 0001328625 Mathers Edward T 1954 GREENSPRING DRIVE SUITE 600 TIMONIUM MD 21093 1 0 0 0 0 Nonstatutory Stock Option (right to buy) 2.27 2023-06-28 4 A 0 30000 0.00 A 2033-06-27 Common Stock 30000 30000 D This option was granted on June 28, 2023. This option is scheduled to fully vest on the earlier of (i) the first anniversary of the date of grant and (ii) the date of the next annual meeting of stockholders of the Issuer held following the date of grant, subject to the recipient's continued service as a director, employee or consultant of the Issuer. /s/ Louis Citron, attorney-in-fact 2023-06-30