SCHEDULE 13G/A 0001104659-25-066695 0001687509 XXXXXXXX LIVE 1 Common Stock, $0.001 par value per share 12/31/2025 0001563880 Trevi Therapeutics, Inc. 89532M101 195 Church Street, 16th Floor New Haven CT 06510 Rule 13d-1(b) Rubric Capital Management LP DE 0.00 3766749.00 0.00 3766749.00 3766749.00 N 2.94 IA PN David Rosen X1 0.00 3766749.00 0.00 3766749.00 3766749.00 N 2.94 HC IN Trevi Therapeutics, Inc. 195 Church Street, 16th Floor, New Haven, CT 06510 This statement is filed by: (i) Rubric Capital Management LP ("Rubric Capital"), the investment adviser to certain investment funds and/or accounts (collectively, the "Rubric Funds") that hold the shares of common stock, par value $0.001 per share (the "Common Stock") of Trevi Therapeutics, Inc., a Delaware corporation (the "Issuer") reported herein; and (ii) David Rosen ("Mr. Rosen"), Managing Member of Rubric Capital Management GP LLC, the general partner of Rubric Capital. The foregoing persons are hereinafter sometimes collectively referred to as the "Reporting Persons." The filing of this statement should not be construed as an admission that any of the forgoing persons or any Reporting Person is, for the purposes of Section 13 of the Act, the beneficial owner of the Shares reported herein. The address of the principal business office of each of the Reporting Persons is 155 East 44th St, Suite 1630, New York, NY 10017. Rubric Capital is a Delaware limited partnership. Mr. Rosen is a citizen of the United States of America. N IA HC The information required by Item 4(a) is set forth in Row 9 of the cover page for each of the Reporting Persons and is incorporated herein by reference. The percentage set forth in Row (11) of the cover page for each of the Reporting Persons and in Item 4(b) is based on the 128,230,134 shares of Common Stock outstanding as of October 31, 2025, as reported in the Issuer's Quarterly Report on Form 10-Q for the quarterly period ended September 30, 2025 filed with the Securities and Exchange Commission on November 13, 2025. 2.94 The information required by Item 4(c)(i) is set forth in Row 5 of the cover page for each of the Reporting Persons and is incorporated herein by reference. The information required by Item 4(c)(ii) is set forth in Row 6 of the cover page for each of the Reporting Persons and is incorporated herein by reference. The information required by Item 4(c)(iii) is set forth in Row 7 of the cover page for each of the Reporting Persons and is incorporated herein by reference. The information required by Item 4(c)(iv) is set forth in Row 8 of the cover page for each of the Reporting Persons and is incorporated herein by reference. N Y N See Item 2(a). Y Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11. Rubric Capital Management LP /s/ Michael Nachmani 02/13/2026 David Rosen /s/ David Rosen 02/13/2026