X0306 4 2020-06-29 0 0001563880 Trevi Therapeutics, Inc. TRVI 0001313403 Colangelo Dominick C/O TREVI THERAPEUTICS, INC. 195 CHURCH STREET, 14TH FLOOR NEW HAVEN CT 06510 1 0 0 0 Nonstatutory Stock Option (right to buy) 6.87 2020-06-29 4 A 0 23684 0.00 A 2030-06-28 Common Stock 23684 23684 D This option was granted on June 29, 2020. This option is scheduled to vest as to (i) 50% of the underlying shares on the earlier of (A) the first anniversary of the date of grant and (B) the date of the first annual meeting of stockholders of the Issuer held following the date of grant and (ii) the remaining 50% of the underlying shares on the earlier of (A) the second anniversary of the date of grant and (B) the date of the second annual meeting of stockholders of the Issuer held following the date of grant. /s/ Frank Muscolo, attorney-in-fact 2020-07-01