X0206 3 2019-05-07 0 0001563880 Trevi Therapeutics, Inc. TRVI 0001641354 Omega Fund V, L.P. 888 BOYLSTON STREET, SUITE 1111 BOSTON MA 02199 0 0 1 0 0001641355 Omega Fund V GP, L.P. 888 BOYLSTON STREET, SUITE 1111 BOSTON MA 02199 0 0 1 0 0001641348 Omega Fund V GP Manager, Ltd. 888 BOYLSTON STREET, SUITE 1111 BOSTON MA 02199 0 0 1 0 0001758535 Mitsak Anna Guyer 888 BOYLSTON STREET, SUITE 1111 BOSTON MA 02199 1 0 0 0 Series C Preferred Stock Common Stock 582230 D Stock Option (Right to Buy) 0.001 2019-05-09 2022-05-06 Common Stock 200000 D The Series C Preferred Stock and the dividends that have accrued thereon to date are convertible on a 9.5-for-one basis into the number of shares of Common Stock shown in Column 3 without payment of further consideration at the holder's election or automatically upon the closing of the Issuer's initial public offering. The number of shares of Common Stock into which the Series C Preferred Stock and accrued dividends thereon are convertible will increase on a daily basis without payment of further consideration as additional dividends accrue. The shares have no expiration date. The reported securities are held directly by Omega Fund V, L.P. ("Omega V"). The reported securities may be deemed to be beneficially owned by each of Omega Fund V GP, L.P. ("Omega V GP"), as the general partner of Omega V, and Omega Fund V GP Manager, Ltd. ("Omega V GP Manager"), as the general partner of Omega V GP. Otello Stampacchia, Richard Lim, Anne-Mari Paster and Claudio Nessi (the "Omega Directors") are all the shareholders and directors of Omega V GP Manager and have shared voting and investment power over the shares held by Omega V. Annie Mitsak, a member of the Issuer's board of directors, has no voting or investment control over any of the shares held by Omega V. Each of Omega V GP, Omega Fund V GP Manager, the Omega Directors and Annie Mitsak disclaims beneficial ownership of the securities reported herein, except to the extent of its or their pecuniary interest therein, if any. Exhibit Index: 24.1 Power of Attorney By: Omega Fund V, L.P., By: Omega Fund GP, L.P., its General Partner, By: Omega Fund V GP Manager, Ltd., its General Partner, /s/ Anne-Mari Paster, Director 2019-05-07 By: Omega Fund GP, L.P., By: Omega Fund V GP Manager, Ltd., its General Partner, /s/ Anne-Mari Paster, Director 2019-05-07 By: Omega Fund V GP Manager, Ltd., its General Partner, /s/ Anne-Mari Paster, Director 2019-05-07 /s/ Annie Mitsak 2019-05-07