X0206 3 2019-05-07 0 0001563880 Trevi Therapeutics, Inc. TRVI 0001403542 Muscolo Frank P C/O TREVI THERAPEUTICS, INC. 195 CHURCH STREET, 14TH FLOOR NEW HAVEN CT 06510 0 1 0 0 Controller Employee Stock Option (right to buy) 3.14 2023-07-10 Common Stock 4903 D Employee Stock Option (right to buy) 3.23 2024-01-22 Common Stock 4515 D Employee Stock Option (right to buy) 2.19 2024-07-01 Common Stock 9005 D Employee Stock Option (right to buy) 1.43 2024-11-24 Common Stock 5989 D Employee Stock Option (right to buy) 3.33 2027-12-19 Common Stock 21052 D This option was granted on July 11, 2013. The 4,903 shares of common stock underlying the option vested as to 25% of the shares on July 11, 2014 and as to the remaining 75% of the shares in equal monthly installments thereafter through July 11, 2017. This option was granted on January 23, 2014. The 4,515 shares of common stock underlying the option vested as to 25% of the shares on January 23, 2015 and as to the remaining 75% of the shares in equal monthly installments thereafter through January 23, 2018. This option was granted on July 2, 2014. The 9,005 shares of common stock underlying the option vested as to 25% of the shares on June 11, 2015 and as to the remaining 75% of the shares in equal monthly installments thereafter through June 11, 2018. This option was granted on November 25, 2014. The 5,989 shares of common stock underlying the option vested as to 25% of the shares on November 25, 2015 and as to the remaining 75% of the shares in equal monthly installments thereafter through November 25, 2018. This option was granted on December 20, 2017. The 21,052 shares of common stock underlying the option vested as to 25% of the shares on December 20, 2018 and are scheduled to vest as to the remaining 75% of the shares in equal monthly installments thereafter through December 20, 2021. Exhibit Index: 24.1 Power of Attorney /s/ Frank P. Muscolo 2019-05-07