X0206 3 2019-05-07 0 0001563880 Trevi Therapeutics, Inc. TRVI 0001229243 VANLENT ANNE C/O TREVI THERAPEUTICS, INC. 195 CHURCH STREET, 14TH FLOOR NEW HAVEN CT 06510 1 0 0 0 Series A Preferred Stock Common Stock 15397 D Series C Preferred Stock Common Stock 5580 D Stock Option (right to buy) 9.12 2028-10-07 Common Stock 18421 D The Series A Preferred Stock and the dividends that have accrued thereon to date are convertible on a 9.5-for-one basis into the number of shares of Common Stock shown in Column 3 without payment of further consideration at the holder's election or automatically upon the closing of the Issuer's initial public offering. The number of shares of Common Stock into which the Series A Preferred Stock and accrued dividends thereon are convertible will increase on a daily basis without payment of further consideration as additional dividends accrue. The shares have no expiration date. The Series C Preferred Stock and the dividends that have accrued thereon to date are convertible on a 9.5-for-one basis into the number of shares of Common Stock shown in Column 3 without payment of further consideration at the holder's election or automatically upon the closing of the Issuer's initial public offering. The number of shares of Common Stock into which the Series C Preferred Stock and accrued dividends thereon are convertible will increase on a daily basis without payment of further consideration as additional dividends accrue. The shares have no expiration date. This option was granted on October 8, 2018. The 18,421 shares of common stock underlying the option are scheduled to vest over four years from the date of grant in equal quarterly installments. Exhibit Index: 24.1 Power of Attorney /s/ Anne VanLent 2019-05-07