X0206 3 2019-05-07 0 0001563880 Trevi Therapeutics, Inc. TRVI 0001774702 Mazabraud Yann C/O TREVI THERAPEUTICS, INC. 195 CHURCH STREET, 14TH FLOOR NEW HAVEN CT 06510 0 1 0 0 See Remarks Employee Stock Option (right to buy) 3.33 2027-12-19 Common Stock 5263 D Employee Stock Option (right to buy) 9.12 2028-08-31 Common Stock 98562 D This option was granted on December 20, 2017. The 5,263 shares of common stock underlying the option vested as to 25% of the shares on December 20, 2018 and are scheduled to vest as to the remaining 75% of the shares in equal quarterly installments thereafter through December 20, 2021. This option was granted on September 1, 2018. The 98,562 shares of common stock underlying the option are scheduled to vest as to 25% of the shares on July 1, 2019 and as to the remaining 75% of the shares in equal monthly installments thereafter through July 1, 2022. Chief Commercial Officer and Head of International Exhibit Index: 24.1 Power of Attorney /s/ Frank P. Muscolo as attorney-in-fact for Yann Mazabraud 2019-05-07