Note 12 - Kissei Agreement (Details) (Kissei Pharmaceuticals Co. Ltd. [Member], USD $) In Millions, unless otherwise specified	1 Months Ended	6 Months Ended
Apr. 30, 2010	Jun. 30, 2013
Kissei Pharmaceuticals Co. Ltd. [Member]
Note 12 - Kissei Agreement (Details) [Line Items]
Upfront Payment Related to Licensing Agreement	$ 3.0
Revenue Recognition, Milestone Method, Revenue Recognized		$ 5.0

The amount of consideration recognized during the period for the milestone or milestones.

Reference 1: http://www.xbrl.org/2003/role/presentationRef

-Publisher FASB

-Name Accounting Standards Codification

-Topic 605

-SubTopic 28

-Section 50

-Paragraph 2

-Subparagraph (e)

-URI http://asc.fasb.org/extlink&oid=19771982&loc=SL6892177-166501

Name:	us-gaap_RevenueRecognitionMilestoneMethodRevenueRecognized
Namespace Prefix:	us-gaap_
Data Type:	xbrli:monetaryItemType
Balance Type:	credit
Period Type:	duration